Vaginal adhesion preparation containing nano silver and its preparing process

A nano-silver and preparation technology, applied in the field of medicinal chemistry and pharmaceutical preparations, can solve problems such as affecting the adhesion of bioadhesive preparations

Inactive Publication Date: 2006-11-08
上海双健药物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) Although the gastrointestinal mucosa has a very large surface area, the presence of food and digestive juices significantly affects the adhesion of bioadhesive preparations to the gastrointestinal mucosa

Method used

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  • Vaginal adhesion preparation containing nano silver and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: prepare the vaginal adhesive preparation of nano silver

[0042] composition

[0043] Cetyl Alcohol 3%

[0044] Stearyl Alcohol 8.5%

[0045] Glyceryl Monostearate 2.5%

[0046] Propylene Glycol 10%

[0047] Tween 80 2%

[0048] Nano silver dispersion (2000ppm) 3%

[0049] Benzoic acid 0.1%

[0050] Sodium hydroxide to adjust pH to 4.0

[0051] water to 100%

[0052] Prepare vaginal adhesion cream according to the following preparation process:

[0053] Put cetyl alcohol, stearyl alcohol, glyceryl monostearate and Tween 80 in a suitable container and heat it to 80°C and keep it warm as the oil phase; the water phase consists of propylene glycol, benzoic acid and an appropriate amount of water In another container, add sodium hydroxide to adjust the pH value, heat to 80°C and keep it warm. Add the water phase into the oil phase under the condition of stirring, emulsify, continue to stir and cool to 40° C., and add the nano-silver solution. The cr...

Embodiment 2

[0054] Embodiment 2: prepare the vaginal adhesive preparation of nano silver

[0055] composition

[0056] Cetyl Alcohol 2%

[0057] Stearyl Alcohol 11%

[0058] Isopropyl Palmitate 4%

[0059] Propylene Glycol 5%

[0060] Tween 80 1.5%

[0061] Nano silver dispersion (2000ppm) 0.5%

[0062] Sorbic acid 0.1%

[0063] Potassium hydroxide to adjust pH to 4.0

[0064] water to 100%

[0065] Embodiment 2 is made cream by the preparation method under embodiment 1.

Embodiment 3

[0066] Embodiment 3: prepare the vaginal adhesive preparation of nano silver

[0067] composition

[0068] Cetyl Alcohol 5%

[0069] Stearyl Alcohol 15%

[0070] Isopropyl Myristate 2.5%

[0071] Propylene Glycol 10%

[0072] Tween 80 4%

[0073] Nano silver dispersion (2000ppm) 10%

[0074] Lactic acid 0.1%

[0075] Sodium hydroxide to adjust pH to 3.8

[0076] water to 100%

[0077] Embodiment 3 is made cream by the preparation method under embodiment 1.

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Abstract

The present invention provides vaginal adhesion preparation containing nanometer silver and its preparation process. The vaginal adhesion preparation contains nanometer silver, higher fatty alcohol, fatty acid ester, propylene glycol, surfactant, water, antioxidant, preservative, etc. and may also contains extracted plant volatile oil, polymer, buffering salt, spermicide, etc. The preparation of the present invention has high and stable viscosity at body temperature and can detain inside vagina for long time.

Description

technical field [0001] The invention relates to the fields of medicinal chemistry and pharmaceutical preparations, in particular, the invention relates to a vaginal adhesive preparation containing nano-silver and a preparation method thereof. Background technique [0002] Nano silver is a material made by nanotechnology. Silver can combine with the sulfhydryl group in the metabolic enzyme of pathogenic bacteria to inactivate the enzyme, and the pathogenic bacteria cannot metabolize and die; it reacts with peptidoglycan exposed on the bacterial cell wall to form a reversible complex, making it unable to transport oxygen into the environment. Cells, preventing the activity of germs and causing their death; the DNA in pathogenic bacteria binds, and the silver ions combined with DNA bases form cross-links with each other, resulting in denaturation of DNA structure, inhibiting its replication, and inactivating pathogenic bacteria. [0003] Korean patent PCT / KR2003 / 002855 disclos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K9/00A61K36/9066A61P15/02A61P31/04
Inventor 顾茂健任福正梁伟蒋宗润
Owner 上海双健药物技术有限公司
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