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High purity wild Radix scutellariae glucoside medicine composition, and application of making medicine to treat diseases of cardiovascular and cerebrovascular

A scutellarin and high-purity technology, which is applied in the field of high-purity scutellarin pharmaceutical compositions, can solve problems such as difficulty in ensuring long-term medicinal requirements, content reduction, and the like, and achieve reliable pharmacological effects.

Active Publication Date: 2006-11-15
CHIATAI QINGCHUNBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the conventional process is made into injection or other liquid preparations, it will also degrade during storage, resulting in a decrease in content, and it is generally difficult to guarantee long-term medicinal requirements
There is no long-term stable scutellarin injection product on the market before the present invention

Method used

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  • High purity wild Radix scutellariae glucoside medicine composition, and application of making medicine to treat diseases of cardiovascular and cerebrovascular

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prescription: scutellarin powder 40g

[0025] Polysorbate 80 4g

[0026] Vitamin C 20g

[0027] Sodium bicarbonate amount

[0028] Add water for injection to 20000ml

[0029] Add 40g of scutellarin powder into 10000ml of water for injection, add sodium bicarbonate solution until completely dissolved; add 4g of polysorbate 80, 20g of vitamin C and stir for 5 minutes, the main drug and auxiliary materials have been dissolved; add water for injection until The whole amount is adjusted to pH=7.05 with sodium bicarbonate solution, finely filtered, potted, and sterilized to obtain scutellarin injection. The content is 98.8%, and the pH value is 7.0; after measurement and calculation, the content is 96.3%, and the pH value is 6.80 after being stored in the dark at room temperature for one and a half years. (Nitrogen filling protection in the whole process)

Embodiment 2

[0031] Prescription: scutellarin powder 40g

[0032] EDTA-2Na 6g

[0033] Vitamin C 20g

[0034] Sodium bicarbonate amount

[0035] Add water for injection to 20000ml

[0036] Add 40g of scutellarin powder into 10000ml of water for injection, add sodium bicarbonate solution until completely dissolved; add 6g of EDTA-2Na, 20g of vitamin C and stir for 5 minutes, the main drug and auxiliary materials have been dissolved; add water for injection to the full amount , adjust pH=6.95 with sodium bicarbonate solution, fine filter, potting, and sterilize to obtain scutellarin injection. The content is 98.7%, and the pH value is 6.91. After measurement and calculation, the content is 96.5%, and the pH value is 6.87 after being stored at room temperature in the dark for one and a half years. (Nitrogen filling protection in the whole process)

Embodiment 3

[0038] Prescription: scutellarin powder 40g

[0039] Vitamin C 10g

[0040] Sodium bicarbonate amount

[0041] Add water for injection to 20000ml

[0042] Add 40g of wild scutellarin powder into 10000ml of water for injection, add sodium bicarbonate solution until completely dissolved; add 10g of vitamin C, stir for 5 minutes, the main drug and auxiliary materials have been dissolved; The sodium solution was used to adjust the pH to 7.10, finely filtered, potted, and sterilized to obtain the scutellarin injection. The content is 98.5%, and the pH value is 7.02. After measurement and calculation, the content is 96.8%, and the pH value is 6.91 after being stored at room temperature in the dark for one and a half years. (Nitrogen filling protection in the whole process)

[0043]

Sample source

Content stability

0 months

June

December

18 months

Example 1

98.8％

98.2％

97.1％

96.3％

Example 2

98.7％...

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PUM

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Abstract

A composite medicine in the form of solution for treating cardiovascular and cerebrovascular diseases features that it contains high-purity wild-scutelloside and pH regulator proportionally and the content of said high-purity wild-scutelloside can be stabilized for at least 18 months.

Description

technical field [0001] The invention relates to a high-purity scutellarin pharmaceutical composition and its medical application in the preparation of cardiovascular and cerebrovascular medicines. Background technique [0002] Scutellarin, also known as scutellarin, baicalein, scutellarin, scutellarin, and baicalin (from the Handbook of Active Ingredients in Plant Medicine: People's Medical Publishing House, March 1986, first edition, p946 ), the chemical name is 4′, 5, 6-trihydroxyflavone-7-O-glucuronide. Its structural formula is as follows: [0003] [0004] Scutellaria altissima L. leaves of labial plants, Scutellaria altissima L. leaves, stems and leaves of Scutellaria baicalensis Georgi, Erigeronbreviscapus (Vant.) Hand-Mazz and other plants of Compositae have a certain content of scutellarin . [0005] Erigeron breviscapus (Vant.) Hand-Mazz is a flavonoid active ingredient isolated from the whole herb of Erigeron breviscapus (Vant.) Hand-Mazz. It is a flavonoid ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/08A61P9/00
Inventor 徐豫杭张善飞潘迎锋刘晓云柴建国张建兵尤国鸿葛晶晶张丽张平
Owner CHIATAI QINGCHUNBAO PHARMA
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