Method for preparing extractive of traditional Chinese medicine sarsa and its quality control method

A quality control method and extract technology are applied in the preparation of traditional Chinese medicine smilax smilax extract, the preparation of traditional Chinese medicine extracts, the quality control field of the smilax miltiorrhiza extract, and can solve the problems of low content of total saponins in smilax miltiorrhiza

Inactive Publication Date: 2006-11-15
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the problem that the extraction and refining method of Smilax is backward and the content of total saponins in Smilax is low, the present invention provides a new extraction and refining method to solve the problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of Smilax Capsules

[0023] Take 7500g of Smilax smilax, add water and decoct three times, each time for 2 hours, add 8 times the amount of water, combine the decoction, filter, centrifuge (4000rpm / min), and concentrate the filtrate under reduced pressure to a relative density of 1.20-1.25 (80°C). After cooling to room temperature, add ethanol to make the alcohol content reach 40%, let it stand for 24 hours in refrigeration, filter, and recover ethanol from the filtrate under reduced pressure, and continue to concentrate to a relative density of 1.20-1.25 (80°C), spray dry (inlet temperature 190±5°C, outlet air temperature 100±5°C); take the dry extract powder, pack it into capsules, and make 1000 capsules, to get final product.

[0024] This product is a capsule, the contents are brown, slightly fragrant, bitter and astringent.

Embodiment 2

[0026] Preparation of Smilax soft capsules

[0027] Take 7500g of Smilax smilax, add water to decoct twice, each time for 3 hours, add 6 times the amount of water, combine the decoction, filter, centrifuge (4000rpm / min), and concentrate the filtrate under reduced pressure to a relative density of 1.20-1.25 (80°C) , to be cooled to room temperature, add ethanol to make the alcohol content reach 60%, let it stand for 24 hours in refrigeration, filter, and recover the ethanol from the filtrate under reduced pressure, and continue to concentrate to a relative density of 1.20~1.25 (80°C), spray dry (into the air) temperature 190±5°C, air outlet temperature 100±5°C); take the dry extract powder, add vegetable oil to a total of 500g, mix evenly, grind in a colloid mill for 20 minutes, pack into capsules, and make 1000 soft capsules, that is, .

[0028] This product is a soft capsule, the content is brown liquid, slightly fragrant, bitter and astringent.

Embodiment 3

[0030] Preparation of Smilax Injection

[0031] Take 7500g of sarsaparilla, decoct twice with water, 2 hours each time, add 8 times the amount of water for the first time, add 6 times the amount of water for the second time, combine the decoction, filter, centrifuge (4000rpm / min), and decompress the filtrate Concentrate to a relative density of 1.20-1.25 (80°C), wait to cool to room temperature, add ethanol to make the alcohol content reach 40%, let it stand for 24 hours in refrigeration, filter, and recover the ethanol from the filtrate under reduced pressure, and continue to concentrate to a relative density of 1.20- 1.25 (80°C), add water to dissolve, extract 5 times with n-butanol, combine n-butanol liquid, recover thick paste after n-butanol is dissolved in water, then absorb on a macroporous resin column, elute with 70% ethanol solution, Collect the ethanol solution, recover the ethanol to a relative density of 1.20-1.25 (80°C), add appropriate amount of water for inject...

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Abstract

A process for extracting the active components from China root greenbrier rhizome includes such steps as decocting in water, depositing in alcohol, and refining by macroreticular resin column. Its quality control method is also disclosed.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine extract, in particular to a preparation method of a traditional Chinese medicine smilax extract, and also relates to a quality control method of the smilax extract, which belongs to the field of traditional Chinese medicine. Background technique [0002] Smilax is a plant of Liliaceae, and the rhizome of the plant contains a variety of smilax saponins. Studies have shown that the total saponins of Phyllostachys chinensis have physiological activities such as clearing away heat and detoxification, reducing swelling and dissipating stagnation, and are used for gynecological adnexitis and adnexal inflammatory mass, and have a good curative effect. More and more people will pay more and more attention to the method for extracting total saponins from Smilax medicinal materials and the medicinal use of total saponins from Smilax chinensis. At present, the extraction technology o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K125/00A61P15/00G01N21/33G01N30/90
Inventor 高淑英
Owner 北京凯瑞创新医药科技有限公司
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