Compositions and methods for reducing the risk of epileptic occurrence and/or for treatment of seizure disorders

Abstract

The present invention relates to compounds and compositions useful for reducing the risk of epileptic occurrences and / or for alleviating epileptic phenomena in patients. In accordance with the invention, the compounds and compositions have at least the following two components: a) vitamin B6-based component selected from pyridoxal, pyridoxamine, pyridoxine, their pharmaceutically acceptable functional derivatives and salts; and b) at least one antiepileptic drug (AED) or anticonvulsive, neuro-protective drug or nootrope compound or moiety. The invention further relates to methods for preventing epileptic episodes and for alleviating epileptic episodes, as well as methods for reducing side effects of antiepileptic drugs.

Description

field of invention

[0001] The present invention relates to compositions and methods of using such compositions for the treatment and prevention of epilepsy and related disorders. Background of the invention

[0002] Epilepsy is one of the most common chronic neurological disorders. The disease is characterized by recurrent seizures that arise from abnormal and excessive brain neuronal activity and result in episodic disturbances of brain function. Types of epilepsy include partial (symptomatic) and generalized spontaneous seizures. Partial epilepsy is "locally related" and occurs in a limited area of ​​the brain. The general development of epilepsy is not caused by a specific brain lesion or disease, apart from a possible genetic predisposition to produce seizures. Generalized or grand mal seizures include tonic-clonic seizures in which the entire body experiences convulsions. Epilepsy left untreated can become status epilepticus, a potentially fatal neurological emergen...

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