Drop pills of soybean aglycone, and preparation method

A technology of aglycon dripping pills and daidzein, which is applied in the field of oral solid preparation drugs, can solve the problems of low water solubility of daidzein, achieve beautiful appearance, improve water solubility, and solve the effects of low dissolution rate

Inactive Publication Date: 2006-12-06
济南沃德生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problem of low water solubility of daidzein in the prior art, the present invention provides a daidzein dripping pill with good water solubility and a preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Daidzein dripping pills, the main drug is daidzein, the polymer carrier of the pharmaceutical excipients is povidone K30, the matrix is ​​polyethylene glycol 4000, the medicinal liquid includes the main drug and pharmaceutical excipients, and the condensation agent required for the formation of the dripping pills Adopt simethicone oil, wherein the component weight ratio of medicinal liquid is as follows:

[0022] Daidzein 5.0g

[0023] Povidone K30 15.0g

[0024] Macrogol 4000 30.0g

[0025] Each pill weighs 50mg and contains 5mg of daidzein.

[0026] Preparation:

[0027] (1) Mix daidzein and povidone K30, add appropriate amount of ethanol, stir to dissolve, dry under reduced pressure to remove ethanol, and obtain daidzein complex.

[0028] (2) Pass the daidzein compound obtained in step (1) through a 150-mesh sieve, add it to the molten matrix polyethylene glycol 4000, stir well, keep the obtained liquid medicine at a certain temperature of 80°C, and select accord...

Embodiment 2

[0030] As described in Example 1, the difference is that the component weight ratio of the daidzein dripping pills is as follows:

[0031] Daidzein 10.0g

[0032] Povidone K30 12.0g

[0033] Polysorbate 804.0g

[0034] Macrogol 4000 34.0g

[0035] Each pill weighs 60mg and contains 10mg of daidzein.

[0036] Preparation:

[0037] (1) Mix daidzein and povidone K30, add appropriate amount of ethanol, stir to dissolve, dry under reduced pressure to remove ethanol, and obtain daidzein complex.

[0038] (2) Pass the daidzein compound obtained in step (1) through a 150-mesh sieve and mix it with polysorbate 80, add it to the molten matrix polyethylene glycol 4000, stir well, and keep the obtained liquid medicine at a certain temperature of 80°C. Use a dripper with a suitable inner diameter to drop the medicinal liquid into the condensed liquid simethicone, form a pellet, take it out, remove the oil layer on the surface, and inspect it to obtain it.

Embodiment 3

[0040] Daidzein dripping pills, the main drug is daidzein, the polymer carrier of the pharmaceutical excipients is povidone K40, the co-solvent is meglumine, the matrix is ​​polyethylene glycol 4000, the drug solution includes the main drug and pharmaceutical excipients, The condensing agent required for dripping pill forming adopts simethicone oil, wherein the component weight ratio of the liquid medicine is as follows:

[0041] Daidzein 15.0g

[0042] Povidone K30 15.0g

[0043] Meglumine 5.0g

[0044] Macrogol 4000 35.0g

[0045] Each pill weighs 70mg and contains 15mg of daidzein.

[0046] Preparation:

[0047] (1) Mix daidzein and povidone K30, add appropriate amount of ethanol, stir to dissolve, dry under reduced pressure to remove ethanol, and obtain daidzein complex.

[0048] (2) Pass the daidzein compound obtained in step (1) through a 150-mesh sieve and mix it with promethylamine, add it to the molten matrix polyethylene glycol 4000, stir well, keep the obtained...

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PUM

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Abstract

A dripping pill of daidzein is prepared from daidzein and the medicinal auxiliary including high-molecular carrier, cosolvent and matrix. The condensing agent for shaping dripping pill is dimethyl silica oil.

Description

(1) Technical field [0001] The invention relates to a dripping pill containing an active ingredient of daidzein and a preparation method thereof, belonging to the field of oral solid preparation medicine and the technical field of medicine. (2) Background technology [0002] Daidzein is one of the main active ingredients of kudzu root, which can expand coronary arteries, relieve vasospasm, improve myocardial metabolism and function, slowly reduce heart rate, reduce myocardial oxygen consumption, reduce blood viscosity, resist isoproterenol, and reduce capillary Vasospasm, improving microcirculation, daidzein also has an estrogen-like effect, which can significantly improve and eliminate female menopausal symptoms. It is suitable for the treatment of cardiovascular and cerebrovascular diseases, including hypertension and symptomatic hypertension, coronary heart disease, angina pectoris, myocardial infarction, cerebral thrombosis, arrhythmia, vertigo, sudden deafness, etc. It ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/20A61K47/34A61K47/40A61P9/10A61P9/06A61P15/12A61P27/16A61K47/10
Inventor 邵爱霞蔡杏娟孙明丽杨秀梅崔秋菊
Owner 济南沃德生物技术有限公司
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