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A Chinese medicinal composition for treating infant fever caused by exogenous pathogen and preparation method thereof

A technology for exogenous fever and composition, applied in the field of traditional Chinese medicine compositions, can solve problems such as drug resistance, toxic and side effects, and achieve the effects of good antipyretic and safe and reliable clinical application.

Active Publication Date: 2006-12-13
JIANMIN PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many kinds of drugs for treating children with exogenous fever. Although these drugs have different degrees of short-term curative effect, these drugs have different degrees of drug resistance and side effects when taken for a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0028] Experimental example 1, the effect of eliminating pathogenic factors

[0029] 1.1 Antibacterial experiment

[0030] 1.1.1 Antibacterial treatment effect: Take 120 mice weighing 18-22g, half male and half male, and divide them into 6 groups randomly, 20 mice in each group. g / kg (dosage is calculated according to the amount of the original drug), the model group is excipients, the above-mentioned drugs are applied externally on the umbilicus at 2 g / kg, and the positive control group is subcutaneously injected with penicillin sodium, 20,000 u / cause, once / day, for 4 consecutive days, except for the blank control group, the animals in each group were intraperitoneally injected with Staphylococcus aureus solution 0.5ml / only after 24 hours, 5.58×10 per ml 9 bacteria, observe and count the number of dead animals in each group within 4 days, the results are shown in Table 1.

[0031] group

[0032] Compared with the model group (X 2 ) * P>0.05, ** P<0.05

[003...

experiment example 2

[0046] Experimental example 2, heat-clearing effect

[0047] 2.1 The antipyretic effect on rat fever caused by dry yeast: 50 rats with a body weight of 180-220g, half male and half male, were randomly divided into four groups, and 1.62g / kg, 0.81g / kg, 0.405 g / kg, the control group was given 2g / kg excipients, and evenly applied to the abdominal hair removal site, and the positive control group was given 100 mg / kg of analgin by intragastric administration, and the administration was given once. Immediately after administration, inject 20% yeast suspension 10ml / kg subcutaneously in the back, measure the body temperature of the rats at 0.5, 1, 2, 4, and 8 hours after the injection, and compare the body temperature changes of the rats in each group statistically. The results are shown in Table 5:

[0048] group

dosage

(g / kg)

normal rectal temperature

(℃)

Rectal temperature after heating (℃)

0.5h

1h

2h

4h

8h

high ...

experiment example 3

[0055] Experimental example 3, anti-inflammatory effect

[0056] 3.1 The effect of xylene-induced ear swelling in mice: 50 mice of 18-22 g, half male and half male, were randomly divided into 5 groups, and the dosage and method were the same as 1.1.1. kg, administered once, 30 minutes after the administration, the right ear of the mouse was given 0.1ml of xylene to apply to both sides (front and back) of the ear piece, and 1 hour after the application, a 6mm punch was used to punch the same part of the left and right ears The discs were weighed on an analytical balance, and the weight of the right ear piece minus the weight of the left ear piece was the degree of swelling. The results are shown in Table 7 below:

[0057] group

Dose (g / kg)

Degree of swelling (mg)

high dose group

Middle dose group

low dose group

Model control group

Positive counter group

1.04

0.52

0.26

2.0

2.0

4.07±0.960 ****

4.03±0.998...

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PUM

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Abstract

The invention relates to a Chinese pharmaceutical composition for treating fever of children and its preparing process, wherein the composition is prepared from calculus bovis, Bupleurum root, honeysuckle flower, Schizonepeta tenuifolia, cape jasmine, picrorhiza rhizome and menthol through the steps of boiling, and ethanol extracting.

Description

field of invention [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating fever caused by exogenous pathogenic factors in children. Background technique [0002] Exogenous fever in children is mainly caused by upper respiratory tract infection. Colds can occur in children of any age, and the younger the age, the higher the incidence rate. The incidence of colds in children younger than 5 years old accounts for half of the diseases in this age group, and the incidence of colds in children aged 5-12 accounts for 30% of the diseases in this age group. Children with exogenous fever are mostly high fever, which can easily lead to convulsions, dehydration, electrolyte imbalance and serious illness. At present, there are various kinds of medicines for treating children with exogenous fever. Although these medicines have different degrees of short-term curative effect, these medicines have...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P29/00A61P31/00A61P11/00A61K35/413
Inventor 熊富良黄志军石召华徐绍新鞠瑞芬袁铭陈鹏
Owner JIANMIN PHARMA GRP CO LTD
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