Manufacturing method of organic compound particulate

A technology of organic compounds and manufacturing methods, applied in the direction of mixing methods, chemical instruments and methods, medical preparations of non-active ingredients, etc., can solve the problems of drug pollution, yield reduction, noise generation, etc.
CN1878602AInactive Publication Date: 2006-12-13MITSUBISHI CHEM CORP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
MITSUBISHI CHEM CORP
Publication Date
2006-12-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provided the manufacturing method of an organic compound particulate which utilizes a poor solvent depositing method of a continuous system and can quickly and uniformly disperse an organic compound solution in quantities of a poor solvent and which can more easily manufacture the organic compound particulate of <=1 [mu]m volume average grain size. In the manufacturing method of the organic compound particulate, an organic compound solution obtained by dissolving the organic compound in a good solvent which is miscible with the poor solvent and easily dissolves the organic compound is continuously mixed with the poor solvent which hardly dissolves the organic compound to manufacture the organic compound particulate. The organic compound solution is mixed with the poor solvent under ultrasonic irradiation.
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Description

technical field

[0001] The present invention relates to a method for producing organic compound microparticles, in particular, to an organic method for obtaining submicron particles of organic compounds that are poorly soluble in water with a particle size of 1 μm or less by using a continuous poor solvent precipitation method. Method for producing compound microparticles. Background technique

[0002] Organic compounds that are poorly soluble in water, that is, particles of organic compounds with a solubility of less than about 10 mg / mL, are used in a wide range of products such as pharmaceuticals, inks, dyes, lubricants, insecticides, pesticides, fertilizers, and cosmetics. In most cases, the quality of the product can be improved by controlling the particle size.

[0003] For example, in pharmaceuticals, in particular, poorly water-soluble drugs are slow to dissolve and elute, and sometimes cannot be sufficiently dissolved and eluting even though they pass through the ab...

Claims

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