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Ginseng-aconite orally disintegrating tablet and its preparing method

A technology of orally disintegrating tablets and disintegrating agents, which is applied in the field of traditional Chinese medicine, can solve the problems of not finding information about Shenfu orally disintegrating tablets, and achieve the effects of accelerating dissolution, reducing dosage, and reducing bitterness

Inactive Publication Date: 2007-01-10
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Checked the patents and literature, but found no information about the attached orally disintegrating tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0113] (1) Powder coating prescription: 10 grams of effective parts of Aconite, 10 grams of film-forming material polyvinylpyrrolidone, 60001 grams of dispersant polyethylene glycol, 80 grams of organic solvent 60% ethanol;

[0114] Take the effective part of aconite, crush it, pass through a 80-120 mesh sieve, put it into a vibrating fluidized bed equipment, add film-forming materials, dispersants, and use an organic solvent as a coating solution for coating, and the temperature of the wind used to control boiling is 35 ℃, the control air volume is 4 cubic meters per minute, and 20 grams of the effective part of the coated aconite is obtained;

[0115] (2) Preparation prescription: preparation prescription: 5 grams of effective parts of ginseng, 20 grams of coated aconite effective parts, 275 grams of pharmaceutical excipients, wherein the disintegrant is 91 grams of low-substituted hydroxypropyl cellulose (L-HPC) , the filler microcrystalline cellulose is 182 grams, and the ...

Embodiment 2

[0118] (1) Powder coating prescription: 15 grams of aconite effective parts, 30 grams of film-forming material polyvinylpyrrolidone, 60002 grams of dispersant polyethylene glycol, 90 grams of organic solvent 80% ethanol;

[0119] Take the effective part of aconite, crush it, pass through a 80-120 mesh sieve, put it into a vibrating fluidized bed equipment, add film-forming materials, dispersants, and use an organic solvent as a coating solution for coating. The temperature of the wind used to control boiling is 45 ℃, the control air volume is 6 cubic meters per minute, obtains 45 grams of coated aconite effective parts;

[0120] (2) Preparation prescription: preparation prescription: 10 grams of ginseng effective parts, 45 grams of coated aconite effective parts, 245 grams of pharmaceutical excipients, wherein 80 grams of disintegrant croscarmellose sodium (CCNa), The filler nano-microcrystalline cellulose is 160 grams, and the flavoring agent lactose is 5 grams; [ginsenoside ...

Embodiment 3

[0123] (1) Powder coating prescription: 11 grams of effective parts of aconite, 13 grams of film-forming material polyvinylpyrrolidone, 1.2 grams of dispersant polyethylene glycol, 83 grams of ethanol of 65% organic solvent;

[0124] Take the effective parts of aconite, crush them, pass through a 80-120 mesh sieve, put them into a vibrating fluidized bed equipment, add film-forming materials, dispersants, and use organic solvents as coating liquids for coating. The temperature of the wind used to control boiling is 36 ℃, the control air volume is 5 cubic meters per minute, and 24 grams of the effective parts of the coated aconite are obtained;

[0125] (2) Preparation prescription: preparation prescription: 6 grams of effective parts of ginseng, 24 grams of effective parts of coated aconite, 270 grams of pharmaceutical excipients, of which 88 grams are cross-linked polyvinylpyrrolidone (PVPP) as a disintegrant, and micro 179 grams of crystalline cellulose, 3 grams of flavoring...

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Abstract

The present invention discloses a Shenfu oral disintegrant tablet and its preparation method. It is characterized by that said oral disintegrant tablet is made up by using ginseng extract and aconite accessory tube extract, adding other medicinal auxiliary material through a certain preparation process.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a Shenfu orally disintegrating tablet and a preparation method thereof. Background technique [0002] Orally disintegrating tablets are a new pharmaceutical preparation, which can be absorbed through the sublingual mucosa and directly enter the blood, effectively avoiding the first-pass effect, so the dosage is small, safe, and rapid in action. Although it is an oral preparation, it is It can achieve the effect of injection preparations, so it is gradually becoming a hot spot in the field of pharmaceutical companies and research and development. This dosage form is mainly to choose a suitable fast disintegrating agent. The tablet made of it has a certain hardness and a certain degree of looseness. It can be quickly disintegrated into fine particles in the oral cavity without the need of water to assist swallowing when taking it, and the p...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61K9/20A61P9/02
Inventor 张晴龙
Owner 张晴龙
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