Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation of injection for treating cardiovascular disease

A technology for the treatment of drugs and preparation technology, which is applied in the fields of cardiovascular system diseases, drug delivery, drug combination, etc., and can solve the problems of patients being unbearable, reducing the safety of drug use, and unable to guarantee the safety of drug use, etc.

Inactive Publication Date: 2010-06-30
西藏林芝百盛药业有限公司
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the preparation technology of sodium fructose diphosphate still has the following shortcomings and deficiencies at present: one, in order to prevent sodium fructose diphosphate from decomposing in an aqueous solution, the pH of the injection must be adjusted to weak acidity, which will introduce a large amount of acid radical ions. The irritation is large, which is unbearable for some patients, which reduces the safety of drug use; 2. At present, the sodium fructose diphosphate injection is packaged in non-sterile glass bottles, and the injection after filling needs to be sterilized. Experiments have proved that sodium fructose diphosphate The injection was sterilized at 100°C for 30 minutes, and the 5-hydroxymethylfurfural and phosphate produced by sodium fructose diphosphate during the high-temperature sterilization process exceeded the standard
The higher the temperature, the longer the sterilization time, the more serious the above inspection indicators exceed the standard, and if the sterilization temperature and time are shortened, the probability of bacterial contamination of the injection will increase, and the safety of medication cannot be guaranteed.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 2

[0009] Wash the resin column with water for injection. After washing, keep the liquid level of the resin for later use; add 48kg of water for injection into the preparation tank, cool down to below 50°C, add 30kg of solid raw material of sodium fructose diphosphate, and stir to dissolve completely. The good medicine solution is passed through the cation exchange resin column for adsorption exchange; after the medicine solution is put on the column, it is washed with water for injection twice the volume of the resin, and the adsorption flow rate is controlled at 280L / hour; the received medicine solution is added to the preparation tank to adjust it The pH of the liquid medicine is 3.9; add 0.1% activated carbon, stir evenly, filter and decarbonize until clear; filter with 0.45 micron microporous membrane + 0.22 micron sterile microporous membrane, pass all inspections, fill in a sterile container, Instantly.

specific Embodiment approach 3

[0010] Wash the resin column with water for injection. After washing, keep the liquid level of the resin for later use; add 48kg of water for injection into the preparation tank, cool down to below 50°C, add 30kg of solid raw material of sodium fructose diphosphate, and stir to dissolve completely. The good medicine solution is passed through the cation exchange resin column for adsorption exchange; after the medicine solution is put on the column, it is washed with water for injection twice the volume of the resin, and the adsorption flow rate is controlled at 280L / hour; the received medicine solution is added to the preparation tank to adjust it When the pH of the medicinal liquid reaches 4.5, add 0.1% activated carbon, stir evenly, filter and decarbonize until clear, filter with 0.45 micron microporous membrane + 0.22 micron sterile microporous membrane, pass all inspections, fill in a sterile container, Instantly.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A process for preparing the medicine in the form of injection to treat cardiovascular and cerebrovascular diseases includes such steps as regulating pH value of medicinal liquid by cationic exchange resin, filtering by dual millipore membranes, and filling it in aseptic containers.

Description

technical field [0001] The invention relates to a preparation process of drug injection for cardiovascular treatment. Background technique [0002] Sodium fructose diphosphate (FDP) is a cell metabolite that exists in the human body and plays an important role in metabolism. It can promote the metabolism of sugar, provide cellular energy, enhance the antioxidant capacity of red blood cells, enhance the concentration of potassium ions in cells, and relieve Intracellular acidosis can strengthen the contractile function of myocardial cells, so it is an acute cardiovascular treatment drug for acute myocardial infarction, myocardial ischemia, and shock. In the 1970s, it was developed by the Italian company Foscalma. In 1988, the drug entered the domestic market with the approval of the Ministry of Health, and was included in the "Eighth Five-Year Plan" national scientific and technological research plan. In 1995, it was approved by the Ministry of Health as a national fourth-cl...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/70A61K9/08A61P9/00
Inventor 李龙军闫志刚杨秀伟
Owner 西藏林芝百盛药业有限公司