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Compound preparation for treating diphtheritic myocarditis and preparation method thereof

A compound preparation and a technique for myocarditis, which are used in the field of compound preparations for treating diphtheria myocarditis and their preparation, can solve problems such as abnormal conduction system function, cardiac conduction system degeneration, myocardial cell necrosis, etc., and can reduce renal vascular resistance and increase cardiac output. Blood volume, the effect of increasing myocardial contractility

Inactive Publication Date: 2016-12-14
石可燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Diphtheria bacilli have weak invasiveness and only grow and reproduce locally on the skin and mucous membranes where they are damaged. However, the exotoxins produced are extremely toxic. For the peripheral nerves, diphtheria myocarditis mainly involves myocardial cells and the cardiac conduction system. In the early stage of pathological changes, the heart is obviously enlarged, and the myocardial cells are cloudy, swollen, and fatty degeneration, followed by multiple focal hyaline degeneration, granular degeneration, and myocardial degeneration. Cell necrosis, accompanied by polymorphonuclear leukocyte infiltration; in the late stage, there may be hyperplasia of connective tissue, degeneration, necrosis and scar formation of the cardiac conduction system, resulting in abnormal conduction system function

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: This embodiment prepares a kind of compound intravenous infusion solution for the treatment of diphtheria myocarditis, comprises the following composition by weight: diphtheria antitoxin 2 parts, clindamycin 6 parts, captoprine 15 parts 12 parts Polygonatum mucopolysaccharide, 22 parts of adenosine triphosphate, 7 parts of inosine, 9 parts of spironolactone sterone, 11 parts of cyclomandelate, 0.5 parts of antioxidant, 8 parts of emulsifier, 13 parts of buffer.

[0021] Wherein, the Polygonatum polysaccharide is a polysaccharide substance extracted with microwave assistance from Polygonatum odoratum powder. The specific process is: according to the solid-liquid ratio of 1:10, add Polygonatum odoratum powder and warm water at 45°C, then place it in a microwave-assisted extraction apparatus for extraction for 20 minutes, then filter, concentrate the filtrate under reduced pressure to 1 / 2 the volume of the filtrate, and then add and Equal volume of the concen...

Embodiment 2

[0029] Embodiment 2: This embodiment prepares a kind of compound intravenous infusion solution for the treatment of diphtheria myocarditis, comprises the following components by weight: diphtheria antitoxin 4 parts, clindamycin 10 parts, captoprine 18 parts Polygonatum mucopolysaccharide 15.5 parts, adenosine triphosphate 26 parts, inosine 10 parts, spironolactone 12.5 parts, cyclomandelate 14.5 parts, antioxidant 0.7 parts, emulsifier 12 parts, buffer 15 parts.

[0030] Wherein, the Polygonatum polysaccharide is a polysaccharide substance extracted with microwave assistance from Polygonatum odoratum powder. The specific process is: according to the solid-to-liquid ratio of 1:10, add Polygonatum odoratum powder and warm water at 50°C, then place it in a microwave-assisted extraction apparatus for extraction for 25 minutes, then filter, concentrate the filtrate under reduced pressure to 1 / 2 the volume of the filtrate, and then add and Equal volume of the concentrated solution i...

Embodiment 3

[0038] Example 3: This example prepares a compound intravenous infusion solution for the treatment of diphtheria myocarditis, including the following components by weight: 6 parts of diphtheria antitoxin, 14 parts of clindamycin, 21 parts of captopril 19 parts Polygonatum mucopolysaccharide, 30 parts of adenosine triphosphate, 13 parts of inosine, 16 parts of spironolactone sterone, 18 parts of cyclomandelate, 0.9 parts of antioxidant, 16 parts of emulsifier, 17 parts of buffer.

[0039] Wherein, the Polygonatum polysaccharide is a polysaccharide substance extracted with microwave assistance from Polygonatum odoratum powder. The specific process is: according to the solid-liquid ratio of 1:10, add Polygonatum odoratum powder and warm water at 55°C, then place it in a microwave-assisted extraction apparatus for extraction for 30 minutes, then filter, concentrate the filtrate under reduced pressure to 1 / 2 the volume of the filtrate, and then add and Equal volume of the concentrate...

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PUM

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Abstract

The invention discloses a compound preparation for treating diphtheritic myocarditis and a preparation method thereof. The compound preparation is prepared from diphtheria antitoxin, clindamycin, captopril, polygonatum polysaccharide, adenosine triphosphate, inosine, spironolactone, cyclandelate, fructose diphosphate, strophanthin, amiloride, soy protein, isosorbide dinitrate, ubidecarenone and vitamin C. According to the compound preparation, corynebacterium diphtheriae can be killed in time, exotoxin can be reduced, focus can be prevented from expanding, meanwhile, the cardiac load is relieved, the heart function is improved, myocardial contractility is increased, the diphtheritic myocarditis treatment effect is remarkable, safety is achieved, the toxic and side effects are small, and wide application prospects are achieved.

Description

technical field [0001] The invention relates to the technical field of cardiovascular medicine, in particular to a compound preparation for treating diphtheria myocarditis and a preparation method thereof. Background technique [0002] Diphtheria myocarditis is an acute respiratory infectious disease caused by C. Patients can be combined with myocarditis, called diphtheria myocarditis, the most serious complications of diphtheria and the main cause of death. [0003] The mechanism of myocardial damage in diphtheria myocarditis is that diphtheria bacteria release toxins, which interfere with the conversion of amino acids from soluble ribonucleic acid to polypeptide structures, thereby inhibiting protein synthesis. [0004] Diphtheria bacilli have weak invasiveness and only grow and reproduce locally on the skin and mucous membranes where they are damaged. However, the exotoxins produced are extremely toxic. For the peripheral nerves, diphtheria myocarditis mainly involves m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/40A61K9/00A61P9/00A61P31/04A61K31/726A61K31/7076A61K31/7056A61K31/401A61K31/375A61K31/585A61K31/216A61K31/7016A61K31/34A61K31/7048A61K31/4965A61K38/01A61K31/122
CPCA61K9/0019A61K31/122A61K31/216A61K31/34A61K31/375A61K31/401A61K31/4965A61K31/585A61K31/7016A61K31/7048A61K31/7056A61K31/7076A61K31/726A61K38/01A61K39/40A61K2300/00
Inventor 石可燕
Owner 石可燕
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