Unlock instant, AI-driven research and patent intelligence for your innovation.

Identification and assaying method for extractive of flowers and leaves of pseudo-ginseng

An identification method and extract technology, applied in pharmaceutical applications, preparation of Radix Ginseng flower leaf extract, protopanaxadiol ginsenoside field, can solve the unstable content of active ingredients in the extract and the lack of quality control indicators , patients taking inconvenience and other problems, to achieve perfect quality standards, improve process and quality standards, stable product quality and excellent results

Active Publication Date: 2010-05-12
YUNNAN BAIYAO GROUP
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high content of impurities in the product, the active ingredient is less than 3%, and the dosage is very large, each time you need to take 10-15g, containing 0.5-1.5g of the seven-flower leaf extract, three to five times a day, and it is very inconvenient for patients to take it.
At the same time, due to the lack of quantitative quality control indicators, the active ingredient content of each batch of extracts is unstable

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Identification and assaying method for extractive of flowers and leaves of pseudo-ginseng
  • Identification and assaying method for extractive of flowers and leaves of pseudo-ginseng
  • Identification and assaying method for extractive of flowers and leaves of pseudo-ginseng

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0209] Extract the pulverized Tianqi flower leaves twice at 80°C with water heat, concentrate under reduced pressure to obtain an extract with a relative density of 1.07. Mix the extract with 2 times the weight of macroporous adsorption resin JKSD and put it on the column. 5 times column volume of clean water was eluted until colorless, and discarded this part of the eluate. Continue washing with 95% ethanol until colorless, collected the eluate, and obtained the total saponins of Radix chinensis. After measuring the content of ginsenoside Rb1, determine the content of excipients. Add appropriate amount of starch and corresponding excipients to the total saponins of Panax chinensis leaves, mix well, granulate, and press into tablets. The daily dosage of ginsenoside Rb1 is not less than 8mg. It has the effects of clearing away heat, cooling blood, calming the liver, and suppressing yang. It has a good therapeutic effect on acne vulgaris, especially acne vulgaris with blood heat ...

Embodiment 2

[0211] Extract with 60% ethanol solution, heat reflux at 60-70°C for 2 hours, and keep stirring. Extract 3 times. The extract was concentrated under reduced pressure to a relative density of 1.06 (45°C-50°C) extract to obtain a crude extract. The crude extract and the macroporous adsorption resin Amberlite XAD16 in equal weight were mixed well and put on the column, and 5 times column volume of clean water was eluted until colorless, and this part of the eluate was discarded. Continue to rinse with 90% ethanol until it becomes colorless, collect the eluate, and dry it under reduced pressure to obtain the total saponins from the leaves of Seven Flowers. The total saponins of Panax chinensis leaves can be measured for the content of ginsenoside Rb3 to determine the content of auxiliary materials, starch and corresponding auxiliary materials are added, mixed and put into capsules to make capsules. The daily dosage of ginsenoside Rb3 is not less than 16mg. It has the effects of...

Embodiment 3

[0213] Extract Tianqi flower leaves with hot water at 100°C under reflux for 2 to 4 hours, a total of three times. The extract is concentrated under reduced pressure to a relative density of 1.08 (45-50°C) extract. The crude extract and the equal weight of macroporous adsorption resin DA101 were mixed well and put on the column, and 5 times column volume of clean water was eluted until colorless, and this part of the eluate was discarded. Continue to wash with 95% ethanol until it becomes colorless, collect the eluate, and obtain the total saponins from the leaves of Seven Flowers. Vacuum dry. After grinding, determine the content of excipients according to the total content of ginsenosides Rb1, Rb2 and Rb3, add micropowder silica gel and starch, mix and press into tablets to make tablets. The total daily dose of ginsenosides Rb1, Rb2, and Rb3 is not less than 24mg. It has the effects of clearing heat, cooling blood, calming the liver, and suppressing yang. It has a good t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

An extract of the flower and leaf of notoginseng contains 20(s) protopanaxadiol-type saponin compound (ginsenoside Rb1, Rb2 and Rb3), and can be used for treating acne, hypertension and its complications (dizziness, headache, palpitation, insomnia, etc). Its preparing process and quality control method are also disclosed.

Description

technical field [0001] The present invention relates to an extract of tianqi flower leaves, more specifically, the present invention relates to 20(s) propananaxadiol ginsenosides, the main active ingredient in tianqi flower leaves. Simultaneously, the present invention also relates to the preparation method, quality control method and application in pharmaceuticals of the extract of Radix radicis Radix. Background technique [0002] Panax notoginseng (Burk.) F.H.Chen is the above-ground part of Araliaceae plant Tianqi. In the past, the extract of Radix Glycyrrhizae Folium only adopted simple water extraction technology to make granules mainly composed of sucrose or other auxiliary materials (see Chinese Patent No. 97119709.1). However, due to the high content of impurities in the product, the active ingredient is less than 3%, and the dosage is very large, each time you need to take 10-15g, containing 0.5-1.5g of the seven-flower leaf extract, three to five times a day, and...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/906G01N30/90G01N33/15A61P17/10A61P25/20A61P9/12A61K127/00A61K133/00
Inventor 唐书明杨云张力彬李惠娟孟晓春王丽
Owner YUNNAN BAIYAO GROUP