Crystalline form iv of agomelatine, a process for its preparation and pharmaceutical compositions containing it
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A technology of composition and crystal form, applied in the field of new crystal form IV of N-[2-ethyl]acetamide, can solve problems such as no specific description
Inactive Publication Date: 2007-02-07
SERVIER LAB
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However, the document does not specify the conditions under which agomela
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Embodiment 1
[0018] Example 1: Form IV of N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide
[0019] 2θ angle (°)
Embodiment 2
[0020] Embodiment 2: pharmaceutical composition
[0021] Prepare a prescription for 1000 tablets, each containing a 25mg dose:
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Abstract
The crystalline form IV of a compound of formula (I) is characterised by the X diffraction diagram thereof on a powder.
Description
technical field [0001] The present invention relates to agomelatine or a new crystal form IV of N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide of formula (I): [0002] [0003] Its preparation method and pharmaceutical composition containing it. Background technique [0004] Agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, has valuable pharmacological properties. [0005] It does have a dual profile, on the one hand, it is an agonist of receptors of the melatonergic system, on the other hand, it is a 5-HT 2C receptor antagonists. These properties make it active in the central nervous system, more particularly in severe depression, seasonal affective disorder, sleep disturbances, cardiovascular diseases, digestive disorders, insomnia and fatigue due to jet lag, appetite disturbances active in the treatment of obesity. [0006] Agomelatine, its preparation and its therapeutic use are described in European patent specification EP 0 447 285 . [0007] In view of t...
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