Thienopyrimidine and thienopyridine derivatives substituted with cyclic amino group

A cyclic amino and pyrimidine technology, which can be used in drug combinations, digestive system, endocrine system diseases, etc., and can solve problems such as undisclosed compounds
CN1910190AInactive Publication Date: 2007-02-07TAISHO PHARMACEUTICAL CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TAISHO PHARMACEUTICAL CO LTD
Publication Date
2007-02-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, dermatitides, schizophrenia, pain, etc. A thienopyrimidine or thienopyridine derivative substituted with a cyclic amino group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.
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Description

technical field

[0001] The present invention relates to a therapeutic agent for diseases believed to be associated with corticotropin releasing factor (CRF), such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's disease, Eating diseases, hypertension, gastrointestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, traumatic brain injury, inflammation, immune-related diseases, alopecia (alpecia), irritable bowel syndrome, sleep disorders, epilepsy , dermatitis, schizophrenia, pain, etc. Background technique

[0002] CRF is a hormone containing 41 amino acids (Science, 213, 1394-1397, 1981; and J. Neurosci., 7, 88-100, 1987), and it is believed that CRF plays a central role in the biological response against stress ( Cell. Mol. Neurobiol., 14, 579-588, 1994; Endocrinol., 132, 723-728, 1994; and Neuroendocrinol. 61, 445-452, 1995). For CRF, there are two pathways: the pathway by which CRF acts on the peripheral...

Claims

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