Quick-disintegration tablets of calcium atovastatine, and its prepn. method
A technology of atorvastatin calcium and disintegrant, applied in the field of medicine, can solve the problems of delayed disintegration of ordinary tablets, affecting clinical efficacy, inconvenience and the like
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Embodiment 1
[0032] Embodiment 1, prepare 1000 atorvastatin calcium tablets whose specification is 10 mg / tablet, the consumption of each component is as follows:
[0033] Atorvastatin calcium (calculated as atorvastatin) 10.0g
[0034] Microcrystalline cellulose (added inside) 50g
[0035] Microcrystalline cellulose (extra) 25g
[0036] 80g pregelatinized starch
[0037] PVPP (inside) 15g
[0038] PVPP (extra) 5g
[0039] Sodium Lauryl Sulfate 2g
[0040] Sweet Orange Powder Flavor 2g
[0042] 5% pvp aqueous solution appropriate amount
Embodiment 2
[0043] Embodiment two, prepare 1000 atorvastatin calcium tablets of the present invention whose specification is 20 mg / tablet, the consumption of each component is as follows:
[0044] Atorvastatin calcium (calculated as atorvastatin) 20.0g
[0045] Microcrystalline cellulose (added inside) 40g
[0046] Microcrystalline cellulose (extra) 20g
[0047] Lactose 50g
[0048] PVPP (inside) 30g
[0049] PVPP (extra) 10g
[0050] Sodium Lauryl Sulfate 10g
[0051] Cyclamate 10g
[0053] 5% pvp aqueous solution appropriate amount
Embodiment 3
[0054] Embodiment three, prepare 1000 atorvastatin calcium tablets whose specification is 40 mg / tablet, the consumption of each component is as follows:
[0055] Atorvastatin calcium (calculated as atorvastatin) 40.0g
[0056] Microcrystalline cellulose (added inside) 36.5g
[0057] Microcrystalline cellulose (extra) 18.2g
[0058] Powdered sugar 93.1g
[0059] PVPP (inside) 45g
[0060] PVPP (extra) 15g
[0061] Sodium Lauryl Sulfate 5g
[0062] Glycyrrhizin 5.32g
[0063] Silicon dioxide 7.98g
[0064] 5% pvp aqueous solution appropriate amount
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