Insulin liquid formulations for nose administration

Abstract

The invention discloses insulin providing liquid agent through nose, which is characterized by the following: avoiding side-effect due to injecting drug, increasing drug adsorbing area because the nose possesses bigger nasal area (150-180cm<2>) with large scale of microvillus and thinner nasal mucosa (2-4mm), adsorbing drug rapidly due to abundant capillary and capillary lymphangiolog.

Description

technical field

[0001] The invention relates to an insulin preparation, in particular to a liquid preparation for nasal administration of insulin. Background technique

[0002] With the development of biotechnology and genetic engineering, more and more polypeptide and protein drugs are used in clinical treatment, and most polypeptide drugs are biologically active and unstable to heat and enzymes, so they are often given by injection. medicine. However, long-term injection administration brings great pain to patients, and requires special injection techniques, which makes it difficult for patients to administer medicines independently, resulting in high finished products and high medical expenses. Therefore, domestic and foreign pharmaceutical workers have been committed to the research of non-injection routes of polypeptide drugs, such as nasal cavity, rectal, oral, lung, eye, transdermal absorption and so on. Among the above routes of administration, nasal administration...

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