Insulin liquid formulations for nose administration

Abstract

The invention discloses insulin providing liquid agent through nose, which is characterized by the following: avoiding side-effect due to injecting drug, increasing drug adsorbing area because the nose possesses bigger nasal area (150-180cm<2>) with large scale of microvillus and thinner nasal mucosa (2-4mm), adsorbing drug rapidly due to abundant capillary and capillary lymphangiolog.

Description

technical field [0001] The invention relates to an insulin preparation, in particular to a liquid preparation for nasal administration of insulin. Background technique [0002] With the development of biotechnology and genetic engineering, more and more polypeptide and protein drugs are used in clinical treatment, and most polypeptide drugs are biologically active and unstable to heat and enzymes, so they are often given by injection. medicine. However, long-term injection administration brings great pain to patients, and requires special injection techniques, which makes it difficult for patients to administer medicines independently, resulting in high finished products and high medical expenses. Therefore, domestic and foreign pharmaceutical workers have been committed to the research of non-injection routes of polypeptide drugs, such as nasal cavity, rectal, oral, lung, eye, transdermal absorption and so on. Among the above routes of administration, nasal administration...

AI Technical Summary

Problems solved by technology

[0005] Chinese patent [Application No.] 01801146.2, nasal inhalation preparation of insulin, discloses an insulin-containing preparation using porous spherical calcium carbonate as a carrier, wherein the porous spherical calcium carbonate is columnar or needle-like microcrystals or their parallel contiguous crystals Aggregates; the defect of the technology disclosed in this patent is that it only solves the difficulty of long-term retention in the nasal cavity after the adsorption of insulin and the carrier, but does not break through the barrier of insulin absorbed into the body through the nasal mucosa;

[0006] Chinese patent [Application No.] 02125051.0, composition for oral and nasal administration, dry powder inhaler and its preparation method, the invention takes natural milk and natural fragrance as the main line, proposes carrier-free dry powder inhaler composition, inhaler and its Preparation method; the defects in the technology disclosed in this patent are as using natural milk such as milk directly through vacuum spray-drying (or freeze-drying) to prepare the carrier, which is likely to cause protein allergy when inhaled and administered, and insulin itself has no peculiar smell. no flavoring required;

However, sodium glycinate, as an absorption accelerator, has irreversible damage to nasal cilia, and long-term use will cause damage to nasal mucosa

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