Formulation of plant source hard capsule case and preparing method thereof

A hard capsule shell, plant-derived technology, which is applied in the directions of non-active ingredient medical preparations, capsule delivery, pharmaceutical formulations, etc., can solve the problems of high cost and complicated process, and achieves a solution that avoids pollution, has high transparency, and is conducive to drug stability. Effect

Inactive Publication Date: 2007-03-14
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The plant hollow hard capsules currently researched are mainly made of glue extracted from marine plants and seaweeds. They are nat...

Method used

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  • Formulation of plant source hard capsule case and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1. An example of the product formulation of the novel plant-derived hard capsule shell of the present invention is shown in Table 1 (% in the table is a percentage by weight).

[0033] Table 1 Product formula

[0034]

Embodiment 2

[0035] Embodiment 2, the preparation method of plant source hard capsule shell is as follows:

[0036] (1) Weighing:

[0037] According to formula 1 in Table 1, measure 80ml of distilled water and pour it into a beaker, respectively weigh 0.2g potassium chloride, 0.2g sucrose, 0.1g gum arabic, 0.4g carrageenan, 1g polyethylene glycol 400, and 1g glycerol in turn. Put into a beaker and stir.

[0038] (2) Heating to dissolve:

[0039] The beaker was placed in a 60°C water bath, heated and stirred, and 12 g of hydroxypropyl methylcellulose 60HD5 was added to the beaker at 80°C, and stirred to dissolve.

[0040] (3) Gum raising:

[0041] The beaker was thermostated in a water bath at 84°C for 45 minutes.

[0042] (4) Defoaming:

[0043] First add 3-5 drops of ethanol dropwise to the beaker, stir and place for three minutes, then add 2-3 drops dropwise (this step should be determined by the amount of air bubbles).

[0044] (5) Dipping glue:

[0045] Lower the temperature of ...

Embodiment 3

[0051] (1) Weighing:

[0052] According to formula 2 in Table 1, measure 80ml of distilled water and pour it into a beaker, weigh 0.04g of potassium chloride, 0.032g of sucrose, 0.032g of locust bean gum, 0.152g of carrageenan, and 0.472g of polyethylene glycol 400, respectively. Put into a beaker and stir.

[0053] (2) Heating to dissolve:

[0054] The beaker was placed in a 60°C water bath, heated and stirred. At 80°C, 14.02 g of hypromellose 60HD5 was added to the beaker and stirred to dissolve.

[0055] (3)-(7) Steps are the same as in Example 2.

[0056] After testing, the water content of the obtained product was 7.95%.

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Abstract

The invention relates to a formulation of plant source hard gelatin capsule shells and process for preparation, wherein the formulation includes (by weight ratio) 0.01-1.00% of potassium bromide, 0.02-0.80% of sucrose, 0.01-0.80% of acacia gum or locust bean glue, 0.10-2.00% of carrageenan, 0.50-5.20% of plasticizer synergistic agent, 70-90% of distilled water, 9.00-29.00% of methyl hydroxypropylcellulose.

Description

Technical field: [0001] The invention relates to a formula of a novel plant-derived hard capsule shell and a preparation method thereof, which can be applied to the fields of medicine and health food production. Background technique: [0002] Capsules are one of the most commonly used dosage forms of medicines and functional foods. In addition to the contents, the quality of capsules often depends on the quality of the capsule shell, which directly affects the clinical efficacy and safety of capsules. Therefore, improving the shell quality of capsules and developing new capsules is one of the key research directions of contemporary pharmacy. At present, most of the raw materials used in the capsule shells of hard capsules at home and abroad are animal protein colloidal gelatin made of pig or cow skin and bone plus some plasticizers, edible pigments and sunscreens. Evenly and add a certain proportion of water, after heating and melting, the needle dipping method is made by d...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/38
Inventor 张立新孟洁张希琴赵爱云
Owner QINGDAO UNIV
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