Application of human interferon containing pharmaceutical composition in preparation of medicine for preventing and treating virus infection of respiratory tract
A technology of recombinant human interferon and composition, which is applied in the field of medicine and achieves the effect of being beneficial to use and having less side effects
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Embodiment 1
[0078] According to the method on pharmaceutics, prepare the spray, the volume of each bottle is 3.65 milliliters, wherein the active content of recombinant human interferon-α2b (Beijing Yuance Pharmaceutical Co., Ltd.) is 3,000,000 IU / ml, and the human albumin content is 0.5 %, the content of benzyl alcohol is 0.5%, the content of polysaccharide is 0.1%, and the concentration of phosphate buffer is 20mmol / L.
[0079] Each bottle of the product in this embodiment is 3 million IU / mL*3.65mL, and one preventive treatment course is 1 bottle, which is used for 3-5 days, which not only ensures the effective dose of interferon for local use, but also limits the dosage.
[0080] Tests were carried out on animals, and its irritation to mucous membranes and skin lesions was similar to that of normal saline, and no serious side effects were found. Compared with the U.S. IntronA powder injection, its side effects were moderate, while the side effects of the product of this example were neg...
Embodiment 2
[0083] According to the preparation method of the injection, add recombinant human interferon-α1a (Beijing Yuance Pharmaceutical Co., Ltd.) to a phosphate buffer solution with a pH of 7, so that the active content of the interferon is 1 million IU / mL, and add benzyl alcohol as a preservative , The weight content is 0.5%.
Embodiment 3
[0085] With reference to the method of Example 2, the obtained injection was divided into vials, 1.5 milliliters per bottle, and freeze-dried to obtain a freeze-dried powder injection.
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