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Isoxazoline-substituted benzamide compound and noxious organism control agent

A technology of benzamides and compounds, applied in the field of pest control agents, can solve the problems of undisclosed and unknown usefulness of pest control agents

Active Publication Date: 2007-03-14
NISSAN CHEM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no disclosure about any 4-(5-substituted-5-substituted aryl-4,5-dihydroisoxazol-3-yl)benzamide compound of the present invention, and the compound is used as a pest control The usefulness of the agent is also completely unknown

Method used

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  • Isoxazoline-substituted benzamide compound and noxious organism control agent
  • Isoxazoline-substituted benzamide compound and noxious organism control agent
  • Isoxazoline-substituted benzamide compound and noxious organism control agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0828] Hereinafter, as examples, the synthesis examples and test examples of the present invention will be described in more detail, but the present invention is not limited to these.

Synthetic example 1

[0831] Production of the compound of the present invention using L-COS (a parallel liquid layer synthesis device manufactured by MRITEX).

[0832] Weigh n-propylamine, isopropylamine, sec-butylamine, tert-butylamine, n-pentylamine, 2,2-dimethylpropylamine, n-hexylamine, cyclohexylamine, and benzylamine in 15 L-COS reaction tubes equipped with a stir bar , 4-Trifluoromethylbenzylamine, 1-phenylethylamine, 2-phenylethylamine, 2-(4-phenoxyphenyl)ethylamine, 3-phenylpropylamine and trans-2-phenyl The cyclopropylamine is 1.5 mmol each, covered with a lid and set in the L-COS reaction tank. Stir at room temperature, add 5ml 4-[5-(3,4-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroiso_oxazol-3-yl]benzene to each reaction tube N,N-dimethylformamide-chloroform (1:3) solution (0.2mmol / ml) of formic acid, 1ml 4-(dimethylamino)pyridine in chloroform solution (0.25mmol / ml), and then inject sequentially 1.5 ml of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride in chloroform (1.0 mmol...

Synthetic example 2

[0849] Production of the compound of the present invention using L-COS (Parallel Liquid Layer Synthesis Apparatus from MRITEX).

[0850] Paste the numbers 1-10 on the 10 L-COS reaction tubes equipped with a stir bar, weigh 1.0mmol 3-chloro-4-fluorophenylboronic acid in the No.1 and No.6 reaction tubes, Weigh 1.0mmol 3,5-bis(trifluoromethyl)phenylboronic acid in the reaction tubes of .2 and No.7, and weigh 1.0mmol 3-trifluoromethylbenzene in the reaction tubes of No.3 and No.8 Boronic acid, weigh 1.0 mmol 3-trifluoromethoxyphenylboronic acid in No.4 and No.9 reaction tubes and weigh 1.0 mmol 2-naphthylboronic acid in No.5 and No.10 reaction tubes, then , Add 0.05mmol dichlorobis(triphenylphosphine)palladium(II) to each reaction tube, seal it with nitrogen, cover it, and set it in the L-COS reaction tank. Stir at room temperature, and inject 3ml of 2-bromo-3,3,3-trifluoropropane in 1,2-dimethoxyethane solution (0.5mmol / ml) and 1.5ml of water into each reaction tube. Then, 1 ml of a ...

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PUM

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Abstract

An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A 1 , A 2 and A 3 independently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., X is halogen atom, C 1 -C 6 haloalkyl, etc., Y ia halogen atm, C 1 -C 6 alkyl, etc., R 1 is C 1 -C 12 alkyl arbitrarily substituted with R 16 , C 3 -C 12 alkenyl, arbitrarily substituted with R 16 is oxygen atom or sulfur atom, -N(R 20 )R 19 , etc., R 2 is hydrogen atom, C 1 -C 4 alkoxy C 1 -C 6 alkyl, etc., R 3 is C 1 -C 6 haloalkyl, etc., R 16 is halogen atom, cyano, phenyl substituted with (Z) p1 , D-1 to D-60, E-1 to E-49, etc., R 19 is phenyl, phenyl substituted with (Z) p1 , etc., R 20 is hydrogen atom, C 1 -C 6 alkyl, etc., Z is halogen atom, nitro, C 1 -C 4 alkoxy, etc., D-1 to D-60 are 5- or 6-membered aromatic heterocyclic rings, E-1 to E-49 are 5- or 6-membered saturated heterocyclic rings, m is an integer of 0 to 5, n is an integer of 0 to 4, p1 is an integer of 1 to 5. The pesticide containing these compounds.

Description

Technical field [0001] The present invention relates to a novel isoxazoline-substituted benzamide compound and its salt, and a pest control agent characterized by containing the compound as an active ingredient. The pest control agent of the present invention is used in the fields of agriculture and horticulture or animal husbandry and sanitation (internal or external parasite control agents for mammals or birds as domestic animals or pets, or household and public sanitary pests, unpleasant Pest control agents) and other harmful arthropod pest control agents. In addition, the pesticide of the present invention refers to insecticides, acaricides, nematicides, herbicides, fungicides, etc. in the field of agriculture and horticulture. Background technique [0002] So far, with regard to iso-oxazoline-substituted benzamide compounds, it is known to report the use of 4-(5-methyl-5-substituted pyrrolyl-4,5-dihydroiso-oxazol-3-yl)benzamide Synthesis of solid-phase synthesis of derivativ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D261/04C07D261/16C07D413/04C07D413/06C07D413/12C07D417/06C07D417/12C07C25/24C07C43/176C07C43/215C07C205/11C07C251/48C07C271/28C07C323/09C07F7/08A01N43/80C07C43/174C07C205/12C07C211/52C07C255/29C07C255/50C07C255/60C07C281/02
CPCA01N43/80C07C43/1742C07C43/1745C07C205/11C07C205/12C07C211/52C07C251/48C07C255/29C07C255/50C07C255/60C07C281/02C07C323/09C07D261/16C07D413/06C07D413/12C07D417/06C07D417/12C07F7/0812C07D413/04A61K31/421C07D261/04C07D413/14A61P33/04A61P33/06A61P33/10A61P33/12A61P33/14C07C25/13C07C25/24C07C25/02C07C25/06C07C25/08A61K9/0053
Inventor 三田猛志菊池隆正水越隆司八尾坂学菰田充阳
Owner NISSAN CHEM CORP
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