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Medicine composition of red sage and epimedium for treating cardiac and cerebral vascular diseases

A technology of cardiovascular and cerebrovascular diseases and epimedium extract, which is applied in the field of preparations containing the pharmaceutical composition and its preparation, to achieve the effects of reduced dosage, wide application prospects, and improved efficacy

Inactive Publication Date: 2007-03-21
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, using the interaction of epimedium and salvia miltiorrhiza to prepare prescriptions for treating cardiovascular and cerebrovascular diseases has not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] The preparation of embodiment 1 salvia miltiorrhiza extract

[0098] 1. Water extraction process screening experiment

[0099] The amount of water added, extraction time and extraction times had a great influence on the extraction results, so the content of total phenolic acids in Salvia miltiorrhiza and the yield of extract were taken as indicators, and the influence of the three factors on the extraction results was investigated by orthogonal experiment method. The factors and level design are shown in Table 3.

[0100] level / factor

A water amount (times)

B Extraction time (hours)

C extraction times (times)

1

18

3

1

2

20

4

2

3

22

5

3

[0101] Experimental method Weigh 100g of Salvia miltiorrhiza, a total of 9 parts, extract according to the requirements of each column number in Table 3, combine the extracts, filter, concentrate the filtrate and dilute to 500ml...

Embodiment 2

[0131] Example 2 Process Screening Experiment and Preparation of Epimedium Extract

[0132] The amount of water added, extraction time, and extraction times have a greater impact on the extraction results. Therefore, using the content of icariin and total flavonoids as indicators, the orthogonal experiment method was used to investigate the influence of the four factors on the extraction results. The factors and level design are shown in Table 8.

[0133] level / factor

A water amount (times)

B extraction times (times)

C extraction time (hours)

1

16

1

2

2

18

2

3

3

20

3

4

[0134] Experimental method Weigh 100g of Epimedium, a total of 9 parts, extract according to the requirements of each column number in Table 8, combine the extracts, filter, concentrate the filtrate and dilute to 1000ml, and set aside.

[0135] Determination of Total Flavonoids in Epimedium

[0136] Determination...

Embodiment 3

[0163] Example 3: Preparation of Danshen Extract and Epimedium Extract

[0164] Weigh raw materials according to 1000 times of clinical prescription:

[0165] Salvia 2.5kg Epimedium 1.25kg

[0166] The preparation method is as follows:

[0167] (a) Take the prescribed amount of Danshen medicinal powder, decoct twice with water, add 12 times the amount of water for the first time, add 10 times the amount of water for the second time, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure To the concentrated solution with a relative density of 1.08-1.12, add ethanol until the alcohol content reaches 85%, refrigerate for 24 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add hydrochloric acid to adjust the pH value to 2, shake and extract with ethyl acetate 3 times, the combined ethyl acetate solution was evaporated to dryness. The residue was dissolved in acidic water with a pH value of 2, ...

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Abstract

The present invention belongs to the field of medicine technology, and is especially one kind of medicine composition for treating cardiac and cerebral vascular diseases and its preparations and preparation process. The medicine composition is prepared with red sage and epimedium in certain ratio, and may be prepared into different pharmaceutically acceptable forms, preferably injection and orally taken preparation. The medicine composition may be also prepared with red sage extract and epimedium extract. The medicine composition has greatly raised synergistic effect and high stability.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and relates to a medicinal composition prepared from salvia miltiorrhiza and epimedium, a preparation containing the medicinal composition and a preparation method thereof. [Background technique] [0002] Cardiovascular and cerebrovascular diseases have always been known as the number one killer that threatens human health. According to relevant survey reports, there are more than 3 million people who die from cardiovascular and cerebrovascular diseases in my country every year, accounting for 50% of the total number of deaths in my country every year. 75% of people lost their ability to work to varying degrees, and 4% were seriously disabled. In particular, the age of its onset and death is increasingly younger, and how to effectively prevent and treat it has attracted people's attention. [0003] Cardiovascular and cerebrovascular diseases include coronary heart disease, angina pectoris, myo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10A61P9/12A61P3/06A61P7/02
Inventor 蔡军
Owner 海安江理工技术转移中心有限公司
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