Check patentability & draft patents in minutes with Patsnap Eureka AI!

Opioid delivery system

A technology of opioids and delivery devices, applied in drug delivery, liposome delivery, nervous system diseases, etc., can solve problems such as limitations, inappropriateness for ambulatory patients, and low efficacy

Inactive Publication Date: 2007-03-28
YM生物科学公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the use of nitrous oxide is mainly limited to the hospital setting and not suitable for ambulatory patients
Another potential problem with nitrous oxide relates to its low potency whereby high concentrations (over 50%) of nitrous oxide in oxygen must be administered, potentially causing hypoxia

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Opioid delivery system
  • Opioid delivery system
  • Opioid delivery system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0221] Example 1: Theoretical Model of Opioid Delivery

[0222] Examples 2-4 are based on a theoretical model of opioid delivery; this theoretical model is described herein in Example 1 for greater certainty.

[0223] A theoretical model of opioid delivery was programmed into the computer simulation package "Stella" (High Performance Systems, Lebanon, NH). The elements shown in this example, including the figures and text, are adapted from the Stella model representation and explain the programming of the simulation and how the simulation works.

[0224] In the figures, rectangles represent variables indicative of substance accumulation (except as noted below). Open arrows represent inflow or outflow of accumulations, while solid arrows represent elements controlling flow. To simplify representation, some solid arrows are omitted. Ellipses represent model parameters (inputs) and time-independent calculations. Many model parameters and constants were obtained by prior art ...

Embodiment 2

[0239] Example 2: Administration of a Single Opioid

Embodiment 1

[0240] This example is an application of Example 1: A theoretical model of opioid delivery. This example is intended to illustrate by use a theoretical model of opioid delivery; the model parameters do not reflect any particular opioid. In contrast, the model parameters in this example have been designed to clearly demonstrate the self-limiting aspect of the proposed opioid delivery system. This example shows the integration of the four simulations described in Example 1, and the output of the model when the simulations are run.

[0241] (a) Integration of models

[0242] Figures 5A and 5B show elements of the model described in Example 1 in which a single opioid is administered by inhalation. Figure 5 is divided into two parts: Figure 5A and Figure 5B. FIG. 5A includes: a device model 5010 equivalent to the device model shown and explained as a whole in FIG. 3 in Example 1; a pharmacokinetic model 5020 equivalent to a pharmacokinetic model shown and explained as a whole in...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

An opioid formulation for pulmonary administration in the treatment or management of pain, a pulmonary drug delivery device containing, method of administering, kit containing, and uses of same. The formulation contains at least one rapid-onset opioid and preferably also contains a sustained-effect opioid to reduce the frequency of administration. The invention employs the side effects of the opioid formulation to permit patients to self-limit drug intake, thereby avoiding toxicity while achieving analgesia. A pharmacokinetic and pharmacodynamic model is employed to determine optimum drug formulations and optimum parameters for administration.

Description

technical field [0001] The present invention relates to pharmaceutical formulations and methods of administration thereof, and more particularly, to opioid-based analgesics and methods of administration thereof. Background technique [0002] Opioids are among the oldest drugs in existence and have been the main pain-controlling substances. The original opioid opium came from the poppy plant. "Opioids" are natural derivatives of opium, including morphine, methadone and heroin. "Opioid" is a broader class of drugs that includes opioids, opiates, and synthetic drugs that have the same pharmacological effects as opioids. Commonly used synthetic opioids include demerol, fentanyl, alfentanil, sufentanil, and remifentanil. [0003] Opioids are thought to act by binding to mu receptors in the spinal cord and brain, as well as peripheral tissues. Binding to mu receptors induces a wide range of pharmacological effects, including therapeutic effects such as analgesia, which may be ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K31/4468A61K31/454A61K9/72A61K9/127A61M15/00A61P29/00A61K9/00A61K9/22
CPCA61M15/00A61K9/127A61K9/0078A61K31/454A61M11/00A61K9/0073A61K31/485A61K31/4468A61P25/04A61P29/00A61K9/00
Inventor 奥兰多-里卡多·亨史蒂文-路易斯·谢弗黛安娜-海伦·普柳拉
Owner YM生物科学公司
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com