The application of kallidinogen enzyme in preparation of the pharmaceutical used for treatment of tumor

Abstract

This invention discloses a new use of Pancreatic Kininogenase applied in preparation of tumor radiotherapy drugs, which are mainly used in reducing block, improving the transmission of oxygen to tumor issues, raising oxygen partial pressure in tumor issues, having effect of enhancement of radio sensitivity and attenuation of toxicity. Taking Pancreatic Kininogenase and thereafter inhaling gases with different oxygen concentration can raise oxygen partial pressure in tumor issues, enhance the curative effect of tumor radiotherapy and avoid normal issues from aggravation of the poisonous side reaction radiated after inspiration of gases with high or low oxygen concentration as well.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to the application of pancreatic kininogenase in the preparation of medicaments for radiotherapy of tumors. Background technique [0002] Pancreatic Kininogenase, also known as vasodilation, is extracted and purified from mammalian pancreas. It acts on kininogen to release kinin. In the form of local hormones, kinin binds to the kinin B2 receptor present on the vascular endothelium to activate phospholipase, which hydrolyzes membrane phospholipids into arachidonic acid and inositol triphosphate. Then activate the prostaglandin synthesis system and nitric oxide synthesis system, increase the levels of prostacyclin and nitric oxide in the blood, relax blood vessels and inhibit the proliferation of damaged vascular intima. Pancreatic kininogenase itself belongs to the serine protease class, it can catalyze plasminogen to generate plasmin, and the kinin released by it ca...

AI Technical Summary

Problems solved by technology

If you have tried the hyperbaric oxygen chamber method, the oxygen carrier (artificial blood) method and the use of vasodilators (pentoxifylline, etc.) have not achieved satisfactory results

The reason is that although these methods can increase the oxygen level of the tumor, they also significantly increase the partial pressure of oxygen in normal tissues at the same time, and the obvious increase in the partial pressure of oxygen in normal tissues is the main reason for the aggravation of the toxic and side effects of radiation.

Therefore, the toxic and side effects of normal tissues to radiation are increased, making these methods unacceptable. People are looking forward to a method that not only sensitizes but also attenuates the toxicity.

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