Specific ppar excitant for treating negative energy equilibrium

Abstract

The use of a compound of formula (I): an isomer thereof, a prodrug of said compound or isomer, or a pharmaceutically acceptable salt of said compound, isomer or prodrug, in the manufacture of a medicament for the palliative, prophylactic or curative treatment of negative energy balance in ruminants. The use of a compound of formula (I), in the manufacture of a medicament for the palliative, prophylactic or curative treatment of ruminant disease associated with negative energy balance in ruminants, wherein, preferably, the ruminant disease associated with negative energy balance in ruminants is selected from fatty liver syndrome, dystocia, immune dysfunction, impaired immune function, toxification, primary ketosis, secondary ketosis, downer cow syndrome, indigestion, inappetence, retained placenta, displaced abomasum, mastitis, (endo-)-metritis, infertility, low fertility, and lameness.

Description

field of invention [0001] The invention described herein relates to the use of peroxisome proliferator-activated receptor (PPAR) agonists, in particular PPARα agonists, in the treatment of negative energy balance in ruminants, and more particularly, in combination with Applications in Negative Energy Balance (NEB)-Related Diseases in Ruminants. Background of the invention [0002] The ruminant transition period is defined as the period spanning gestation to early lactation. It is sometimes defined as from prepartum to 3 weeks postpartum, but has been extended from 30 days prepartum to 70 days postpartum (J N Spain and W A Scheer, Tri-State Dairy Nutrition Conference, 2001, 13). [0003] Energy balance was defined as energy intake minus energy output, and animals were described as having negative energy balance if energy intake was insufficient to meet requirements for maintenance and production (eg milk). Cows in the NEB must find energy that is missing from their body res...

AI Technical Summary

Problems solved by technology

However, as stated, the interplay of biological processes is complex and knowledge of the important genes, enzymes and endogenous substrates required to optimize energy balance in transition cows is limited

Furthermore, it is not known how much altering PPAR expression can affect yield or quality, lipolysis or gluconeogenesis, since NEFA’s are key substrates for milk and glucose biosynthesis

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