Specific ppar excitant for treating negative energy equilibrium
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An energy balance, ruminant technology, applied in applications, animal feed, animal feed, etc., can solve the problems of complex interaction, limited knowledge, and lack of understanding of PPAR expression, yield or quality.
Inactive Publication Date: 2007-05-02
PFIZER PRODS ETAT DE CONNECTICUT
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Abstract
Description
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However, as stated, the interplay of biological processes is complex and knowledge of the important genes, enzymes and endogenous substrates required to optimize energy balance in transition cows is limited
Furthermore, it is not known how much altering PPAR expression can affect yield or quality, lipolysis or gluconeogenesis, since NEFA’s are key substrates for milk and glucose biosynthesis
Method used
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preparation Embodiment
[0244] In the following formulations, "active ingredient" refers to the compound used in the present invention.
[0245] Formulation 1: Solution for parenteral administration
[0246] components
Amount (mg / 5ml)
active ingredient
Potassium hydroxide
sodium hydroxide
Sodium dihydrogen phosphate
Disodium phosphate
pvp
Methylparaben
water
1-750
0-75
0-75
0-50
0-100
0-50
0-40
Up to 5ml
[0247] or
[0248] Formulation 2: Solution for parenteral administration
[0249] components
Amount (mg / 5ml)
active ingredient
Sodium dihydrogen phosphate
Disodium phosphate
Methylparaben
water
1-750
0-50
0-100
0-40
Up to 5ml
[0250] or
[0251] Formulation 3: Solution for parenteral administration
[0252] components
Amount (mg / 5ml)
active ingredient
Hydroxypropyl beta-cyclodextrin
Methy...
Embodiment 12
[0270] Example 12-: (3-{1-[(4-isopropyl-phenyl)-acetyl]-piperidin-3-yl}-phenoxy)-2-methyl-propionic acid benzyl ester
Embodiment 1-12
[0271] Example 1-12-: (3-{1-[(3-methoxy-phenyl)-acetyl]-piperidin-3-yl}-phenoxy)-2-methyl-propionic acid
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Abstract
The use of a compound of formula (I): an isomer thereof, a prodrug of said compound or isomer, or a pharmaceutically acceptable salt of said compound, isomer or prodrug, in the manufacture of a medicament for the palliative, prophylactic or curative treatment of negative energy balance in ruminants. The use of a compound of formula (I), in the manufacture of a medicament for the palliative, prophylactic or curative treatment of ruminant disease associated with negative energy balance in ruminants, wherein, preferably, the ruminant disease associated with negative energy balance in ruminants is selected from fatty liver syndrome, dystocia, immune dysfunction, impaired immune function, toxification, primary ketosis, secondary ketosis, downer cow syndrome, indigestion, inappetence, retained placenta, displaced abomasum, mastitis, (endo-)-metritis, infertility, low fertility, and lameness.
Description
field of invention [0001] The invention described herein relates to the use of peroxisome proliferator-activated receptor (PPAR) agonists, in particular PPARα agonists, in the treatment of negative energy balance in ruminants, and more particularly, in combination with Applications in Negative Energy Balance (NEB)-Related Diseases in Ruminants. Background of the invention [0002] The ruminant transition period is defined as the period spanning gestation to early lactation. It is sometimes defined as from prepartum to 3 weeks postpartum, but has been extended from 30 days prepartum to 70 days postpartum (J N Spain and W A Scheer, Tri-State Dairy Nutrition Conference, 2001, 13). [0003] Energy balance was defined as energy intake minus energy output, and animals were described as having negative energy balance if energy intake was insufficient to meet requirements for maintenance and production (eg milk). Cows in the NEB must find energy that is missing from their body res...
Claims
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