Albumin combination mensuration reagent of ischemia modification

A technology of albumin and reagents, which is applied in the field of medical clinical chemical in vitro diagnostic reagents, can solve the problems that there is no one recognized

Inactive Publication Date: 2007-05-09
长沙颐康科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The existing technology mainly calculates the concentration of IMA indirectly by measuring the change of absorbance of the concentration of remaining cobalt after albumin binds cobalt. At present, there is no recognized standard product, so each manufacturer may have different methods to indirectly measure IMA

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: a kind of embodiment product of the present invention adopts following raw material and process to make:

[0024] Formula: Dithiothreitol 0.01kg,

[0025] Water 99.99kg.

[0026] Preparation: put the above 0.01 kg of dithiothreitol into a tank filled with the above 99.99 kg of water to dissolve, and the resulting mixed solution is filtered to be the reagent for the determination of ischemic modified albumin.

Embodiment 2

[0027] Embodiment 2: Another kind of embodiment product of the present invention adopts following raw material and process to make:

[0028] Formula: Dithiothreitol 2g,

[0029] 98g of water.

[0030] Preparation: Dissolve the above-mentioned 2g of dithiothreitol in a tank filled with the above-mentioned 98g of water, and the resulting mixed solution is filtered to be a reagent for the determination of ischemia-modified albumin.

[0031] The ischemia-modified albumin (IMA) assay reagent developed by the present invention in accordance with the WS / T 124-1999 reagent quality inspection standard formulated by the health authority meets the design quality requirements. The results show that it can improve the sensitivity of early ischemia test in patients with acute myocardial ischemia. The reagent has produced good social and economic benefits. At present, albumin-cobalt binding assay (Albumin cobalt binding assay, ACB) has been tried to detect IMA. The ischemia-modifie...

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Abstract

An analysis reagent of ischemic modified albumin is prepared from threitol disulfide of 0.01-2% and water of 98-99.99%. It features that said threitol disulfide is dissolved in said water, the mixed solution is filtered to obtain analysis reagent of ischemic modified albumin.

Description

technical field [0001] The invention relates to a medical clinical chemical in vitro diagnostic reagent, in particular to a reagent for measuring ischemia-modified albumin. Background technique [0002] Ischemia-modified albumin (IMA) refers to the ability of albumin to bind transition metals due to the destruction of the amino acid sequence of serum albumin by free radicals when clinical ischemia or reperfusion medical treatment occurs. The albumin whose ability to bind transition metals changes due to ischemia is called ischemia-modified albumin. [0003] Human serum albumin (Human serum albumin referred to as HSA) is a circulating protein, which consists of 585 amino acid sequences (66500Da), and its amino terminal (N-terminus) is a sequence unique to humans. Studies have confirmed that the amino terminal of HSA is the binding site for transition metal cobalt, copper and nickel ions. Compared with the albumin of other animals, the binding points and sites of these metal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/31G01N21/27G01N33/68G06F19/00G06F19/18
Inventor 蒋洪敏吴白平卿子驹张卫华邓君虎
Owner 长沙颐康科技开发有限公司
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