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Amikacin solution containing clustered water used for animal

A technology of amikacin and hexacyclic water, applied in the field of veterinary medicine, can solve the problems of short duration of peak blood drug concentration, poor bioavailability, slow release speed, etc.

Inactive Publication Date: 2007-05-23
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0026] The above is the existing preparation process and detection method of amikacin solution, but the existing amikacin solution has problems such as slow release rate, short time for peak blood drug concentration, and poor bioavailability

Method used

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  • Amikacin solution containing clustered water used for animal
  • Amikacin solution containing clustered water used for animal
  • Amikacin solution containing clustered water used for animal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1: a, select purified water (i.e. pure water) as the raw water, general commercially available qualified pure water, the electrical conductivity is less than 20μs / cm, slowly freeze after standing for several hours, the cooling rate is 2-5 ℃ / cm h, the freezing minimum temperature reaches -30~-50℃, so that the water is fully crystallized, and then thawed. The thawing process is carried out below 10℃, and the melted water is collected and stored in a temperature environment of 4-10℃ in time, that is, get six rings of water;

[0064] b. Add 25g of Amikacin to an appropriate amount of six-ring water to make it fully diluted and stir evenly;

[0065] c. Add 10-40ml of 30% sulfuric acid solution to dissolve it.

[0066] d. Add six-ring water to the full volume of 1000ml, and adjust the pH to 5.0-7.0

[0067] e. Filter.

[0068] f. Semi-finished products are sent for inspection and determination

[0069] g. Filling of qualified products, the filling capacity is 1...

Embodiment 2

[0072] Embodiment 2: The medicine of the present invention can be used to treat Gram-negative bacteria such as Escherichia coli, Pseudomonas aeruginosa, Proteus and the like. It also has good antibacterial effect on Mycobacterium tuberculosis and Staphylococcus aureus. Dosage: mixed drink, 1ml / 1000ml water, free to drink, consecutive 3-5 days.

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Abstract

The invention relates to a method for using Amikeshen to prepare wide-spectrum antibiosis solution, wherein it uses hexacyclic ring water as carrier that adds frozen hexacyclic ring water into Amikeshen solution, to reduce the volume of hydrone group, the viscosity and surface tension, to reduce the expand resistance and accelerate the drug release. The hexacyclic ring water has strong affinity with cell, to improve the treatment effect on animal bacterial and mycoplasma affection.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and relates to a broad-spectrum antibacterial medicine prepared from amikacin, which is used for livestock and poultry bacteria and mycoplasma infection and a preparation method thereof. Background technique [0002] Water is the most important component of all organisms, and the water content of organisms is generally more than 60%. Except for dry products, the water content in food is between 65% and 90%. It can be said that water plays an important role in our life. plays a very important role. Water has many special properties, which have attracted people's attention in recent years. For example: the magazine "Jiangxi Chemical Industry" in the fourth issue of 1997, page 34 "Water for Life, Miraculous Water", introduced water with a structure of six water molecules, the so-called "six-ring water", which has the function of promoting health. [0003] "The Hexacyclic Structure of W...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K47/04A61P31/04
Inventor 李旭东鲍恩东苏建东
Owner TIANJIN RINGPU BIO TECH
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