Eye drop of povidone iodine and preparation process thereof

A technology for povidone-iodine and eye drops, which is applied in the directions of pharmaceutical formulations, synthetic active ingredients of polymeric materials, drug delivery, etc., can solve problems such as inability to be directly used in the eyes, negative effects on the eyes, etc., and achieve no toxic and side effects. , the preparation method is simple

Inactive Publication Date: 2007-05-23
WUHAN YIFAN BIO PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent discloses multiple povidone-iodine external preparations, such as the disclosed ointment of 93111431.4, which cannot be directly used in eyes; as the disclosed povidone-iodine foam agent of CN03143440.1, it cannot be directly used in eyes
There is no literature yet to disclose whether povidone-iodine can be used for the treatment of eye diseases, and whether it has negative effects on the eyes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Povidone-iodine 0.1g

[0012] Potassium iodate 0.05g

[0013] Sodium chloride 0.6g

[0014] Phosphate buffer saline pH 6.5 100ml

[0015] Add a certain amount of phosphate buffer to dissolve the above-mentioned main drug povidone iodine, add sodium chloride and potassium iodate in turn to dissolve, add phosphate buffer to a sufficient amount of 100ml, and aseptically seal and fill in a certain size and specification In a sealed container, it is produced into povidone-iodine eye drops, and the pH of the povidone-iodine eye drops is 6.5.

Embodiment 2

[0017] Povidone-iodine 0.25g

[0018] Potassium iodate 0.05g

[0019] Sodium chloride 0.6g

[0020] Phosphate buffer saline pH 6.5 100ml

[0021] Prepared as above, the pH of povidone-iodine eye drops is (6.5).

Embodiment 3

[0023] Povidone-iodine 0.5g

[0024] Potassium iodate 0.05g

[0025] Sodium chloride 0.6g

[0026] Phosphate buffer saline pH 6.5 100ml

[0027] Prepared as above, the pH of povidone-iodine eye drops is (6.5).

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PUM

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Abstract

The invention relates to a polyketone iodine eyedrops, and relative production, wherein it adds polyketone iodine into osmotic pressure adjuster, stabilizer, and pH adjuster to be dissolved, and using pH adjuster to realize constant volume; pH adjuster at 100 volume units contain 0.1-0.5 units of polyketone iodine, 0.35-0.65 osmotic pressure adjuster mass units, stabilizer at 0.05 mass units; the pH of osmotic pressure adjuster is 6.0-6.8. The invention can treat kinds of ceratitis, with high safety but no side effect.

Description

technical field [0001] The invention belongs to medicines for treating eye diseases, in particular to an eye drop with povidone-iodine as the main medicine. Background technique [0002] Povidone-iodine has been widely used in clinical external disinfectants, and the main function of povidone-iodine is disinfection and antisepsis. The second part of Chinese Pharmacopoeia 2005 edition has been recorded. Chinese patent discloses multiple povidone-iodine external preparations, such as the ointment disclosed in 93111431.4, which cannot be directly used in eyes; as the disclosed povidone-iodine foam in CN03143440.1, it cannot be directly used in eyes either. There is no literature yet to disclose whether povidone-iodine can be used for the treatment of eye diseases, and whether it has negative effects on the eyes. Contents of the invention [0003] The object of the present invention is to provide a kind of povidone iodine eye drop and preparation method for the treatment of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/80A61K9/08A61K47/02A61P31/02A61P31/04A61P31/10A61P31/12A61P27/02
Inventor 曾婕张虹
Owner WUHAN YIFAN BIO PHARMA TECH
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