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Method for degree of homogeneity for different matter

A technology of mixing uniformity and substance, which is applied in the field of using near-infrared spectroscopy as the detection of mixing uniformity of different substances, to achieve the effect of high data accuracy and fast analysis speed

Inactive Publication Date: 2007-05-23
北京中医药大学中药学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is to evaluate the mixing effect according to the change of pH value after mixing cement and soft soil, and it is not suitable for testing the mixing uniformity of most substances, especially pharmaceutical components.

Method used

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  • Method for degree of homogeneity for different matter
  • Method for degree of homogeneity for different matter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] 1) First mix the mother-of-pearl fine powder and the mixed coarse powder of the four herbs (referred to as coarse powder) according to the following ratio:

[0065] Mother of pearl: coarse powder is 1:1;

[0066] Fully mix the above different samples in the mixer for 10-30 minutes, and take samples at different points after mixing: that is, take 4.9-5.1g samples from concentric rings with different radii on the sample plane in the mixer;

[0067] 2) Open the Result Operation software of the near-infrared spectrometer, click the Select workflow button in the work bar, select the one to be run from the workflow, and click OK; the diffuse reflection scanning method is adopted, and the scanning wavenumber range is selected from 11000 to 4000cm -1 Between the bands, perform multiple scans in the selected band, the above multiple scans means that the number of scans is 64 times;

[0068] 3) Pour the collected samples into the sample cups, cover the spring cover, click Go in ...

Embodiment 2

[0074] In this example, the mother-of-pearl fine powder and the mixed coarse powder of Coptis chinensis, Scutellaria baicalensis, gardenia, and turmeric are mixed according to different proportions, and are measured by near-infrared spectroscopy, and the similarity of different samples is calculated to verify the similarity. Whether the degree calculation method can discriminate samples of different proportions.

[0075] 1) First mix the mother-of-pearl fine powder and the mixed coarse powder of the four medicinal materials (referred to as coarse powder) according to the following ratios:

[0076] Mother of pearl: coarse powder is 1:1;

[0077] Mother of pearl: coarse powder is 1:2;

[0078] Mother of pearl: coarse powder is 1:3;

[0079] Mother of pearl: coarse powder is 2:1;

[0080] Mother of pearl: coarse powder is 3:1.

[0081] Fully mix the above different samples in the mixer for 10-30 minutes, and take samples at different points after mixing: that is, take 4.9-5.1...

Embodiment 3

[0090] In addition to using the mathematical processing software attached to the near-infrared spectrometer, the calculation of the similarity of the obtained near-infrared spectral data refers to:

[0091] (1) Create a new model file: open the TQ Analyst software, select New Method in the File menu, enter the file name in the dialog box, select the save path, and click OK;

[0092] (2) Define a name for the model: define a name for the model in the MethodTitle column under the Description tab, and enter a detailed description of the model;

[0093] (3) Select a qualitative modeling algorithm: under the Description tab, select the algorithm as similarity matching in qualitative analysis: Similarity Match;

[0094] (4) Select the optical path type: under the Pathlength tab, select the optical path type as multivariate signal correction (MSC) or standard normalized transformation (SNV) suitable for solid powder samples;

[0095] (5) Define category: In the process of similarity...

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Abstract

This invention relates to a examine method of the different substance mixed uniformity degree of mixed process, the method having the following steps: mix a variety of pharmaceutical preparations in the mixer for 10~30 minutes, take the sample from the sample surface in the mixer; the said sample is loaded in the near-infrared spectrometer sample cup, and using the diffuse reflectance measuring mode, choosing scanning wave scope from 11000~4000cm-1 wave band, multiple scanning in the selected wave band, with frequency of 8, 16, 32, 64 times, to obtain near-infrared spectral data; using mathematical processing software of near-infrared spectrometer to do the first rank derivative process on the near-infrared spectral data, then using similarity matching method, to obtain the similarity value between the sample; according to the similarity value, evaluate the mixed uniformity degree, and the similarity degree of different location being higher, it represents the proportion of various components of these samples being closer, that is, the mixed uniformity degree better.

Description

technical field [0001] The invention relates to a method for detecting the mixing uniformity of different substances, and more specifically, relates to a method for detecting the mixing uniformity of different substances by using near-infrared spectroscopy. Background technique [0002] In the preparation process of pharmaceutical preparations, the uniformity of mixing between different pharmaceutical active ingredients and between drugs and excipients directly affects the stability and uniformity of the quality of the preparation. In the production process of traditional Chinese medicine raw powder preparations, the types of active ingredients are more complex. Some traditional Chinese medicines contain a variety of herbal medicines, animal medicines and mineral medicines. Their specific gravity varies greatly, and it is difficult to mix them. The uniformity of mixing is very important to the quality of the drug. If the control of uniformity is not strict enough during the...

Claims

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Application Information

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IPC IPC(8): G01N21/25G01N15/00
Inventor 乔延江马群史新元顾海鸥卢建秋张卓永
Owner 北京中医药大学中药学院
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