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Method of treating wound by phycotoxins

A technique for wound and wound healing, which is applied in tricyclic 3, wound treatment, anal fissure and other disease fields, and can solve problems such as reduction of anal tension

Inactive Publication Date: 2007-07-04
PHYTOTOX LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment resulted in a reduction in anal tone in all patients at 5 days post-injection

Method used

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  • Method of treating wound by phycotoxins
  • Method of treating wound by phycotoxins

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Ten healthy adult men between the ages of 24 and 48 with normal sphincter tone (resting pressure less than 72 mmHg as measured by anorectal manometry) were studied. Examined subjects had no anorectal pathology such as hemorrhoids, fistulas, or abscesses. Prior to intervention, investigations performed included anorectal manometry, electromyography, hemogram, basic metabolic panel, and urinalysis.

[0054] A dose of 100 active units of GTX2 and GTX3 combined in a ratio of approximately 2:1, with a total volume of 1.0 ml, was used to locally infiltrate both sides of the internal anal sphincter (0.5 ml on each side) with an insulin syringe. GTX2 and GTX3 mixtures were purified using standard purification methods from shellfish collected in the Gulf of Patagonia, Chile, which has been found to be highly contaminated with PSP toxin.

[0055] Anorectal manometry was performed two minutes after the injection. Measure and record resting and spontaneous systolic blood pressure...

Embodiment 2

[0067] Fifty adults, between the ages of 18 and 70, with symptomatic anal fissures, were enrolled in the study to evaluate the effect of reducing anal tension to improve the healing process, eliminate the need for surgical intervention, and provide a safe and effective alternative to ointment, In order to test the efficacy of GTX local infiltration in the treatment of anal fissure.

[0068] Patients were evaluated according to the following inclusion criteria: anterior, posterior, or bilateral excision ulcers, marginal and posterior sclerosis of medial anal sphincter level fibers, symptoms of post-defecation or persistent pain, bleeding, or a combination of the former. Patients with two history of anal fissures or the course of the disease are chronic. Table 3 contains details of the patients selected for the study. Patients younger than 18 or older than 70 were excluded from the study, as were those who were pregnant, or those whose anal fissures were involved in other condi...

Embodiment 3

[0086] One active unit corresponds to the amount of the composition of the invention necessary to block the muscular contraction of the biceps femoris muscle of the leg of 20 g of CF1 albino strain mice for 1.5 to 2.0 hours. Toxin was injected intramuscularly into the biceps femoris of the right leg of the mice in a volume of 0.5 ml. The left leg was used as a control. This was done in three mice and the paralysis was measured every 30 minutes for the first two hours, then every 2, 4, 8 hours and overnight. Depending on the dose injected, the paralysis can last 24 hours or longer.

[0087] This example demonstrates the reversible nature of the action of the toxin of the present invention and shows that the duration of action can be controlled by varying the dose of toxin.

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PUM

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Abstract

Pharmaceutical compositions comprising tricyclic 3,4-propinoperhydropurines and uses thereof for treating wounds, anal fissure, achalasia, disorders of the upper and lower esophageal sphincter, gastroparesis, hypertrophic pyloric stenosis, hemorrhoids, proctalgia fugax, irritable bowel syndrome, muscular spasms, vasospastic disorders, disorders involving uterine, or bladder spasm, sphincter of Oddi dysfunction, and short-segment Hirschprung's are provided. Also provided are methods of treating wounds and muscle disorders by administering the composition of the invention to a muscle or in the vicinity of a muscle either topically or by injection.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing a heterocyclic guanidine type compound and its application in treating wounds. More specifically, the present invention relates to tricyclic 3,4-propino-perhydropurines, and their use in the treatment of wounds, especially for the treatment of anal fissures and other diseases. Background technique [0002] Paralytic shellfish poisoning (PSP) is caused by a mixture of algal toxins that reversibly bind to receptor sites on voltage-gated sodium channels found in excitable cells. The main clinical symptom is acute paralytic disease. Phycotoxins or saxitoxins are produced by tiny planktonic algae. These toxins accumulate in filter-feeding organisms such as bivalves. Consumption of shellfish contaminated with phycotoxins causes six diseases in humans: PSP, diarrheal shellfish poisoning (DSP), amnesic shellfish poisoning (ASP), neurotoxic shellfish poisoning (NSP), ciguatera toxin ( ...

Claims

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Application Information

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IPC IPC(8): A61F2/00
Inventor 内斯特·安东尼奥·拉戈斯·威尔逊
Owner PHYTOTOX LTD
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