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Molecularly imprinted polymer

a technology of imprinted polymer and imprinting, which is applied in the field of molecular imprinting polymer, can solve the problems of lack of general procedure for polymer synthesis and practicability, and achieve the effect of rapid development and optimization

Inactive Publication Date: 2003-07-17
CRANFIELD UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the factors limiting their practical application is the absence of a general procedure for polymer synthesis.

Method used

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  • Molecularly imprinted polymer
  • Molecularly imprinted polymer
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Examples

Experimental program
Comparison scheme
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first embodiment

[0020] The first embodiment describes the design of a virtual library of functional monomers which possess polymerizable residues and residues, able to interact with a template through electrostatic, hydrophobic van-der-Waals forces, dipole-dipole interactions or reversible covalent bonds. The library of functional monomers should contain at least two, and preferably more monomers which can be vinyl monomers, allyl monomers, acetylenes, acrylates, methacrylates, amino acids, nucleosides, nucleotides, sugars and saccharides, carbohydrates, phenols, heterocycles, aniline, and their derivatives. Preferable monomers are these able to interact with the template through non-covalent interactions and be polymerized through a radical mechanism.

second embodiment

[0021] The second embodiment describes the design of a molecular model of the template using molecular mechanical methods. The template is selected from a group including biological receptors, nucleic acids, immunosuppressants, hormones, heparin, antibiotics, vitamins, drugs, cell components and components of viruses such as carbohydrates, lipids, saccharides, nucleoproteins, mucoproteins, lipoproteins, peptides and proteins, glycoproteins, glucosaminoglycanes and steroids.

third embodiment

[0022] The third embodiment describes screening the virtual library of functional monomers for their ability to form a molecular complex with the template. The monomers giving the highest binding score represent the best candidates for polymer preparation and can be used directly for the polymer synthesis as part of a monomer mixture.

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Abstract

To facilitate preparation of a molecularly imprinted polymer (MIP) which specifically binds a particular template substance, a virtual library of functional monomers is screened to find those that interact strongly with a molecular model of the substance. A selected few are then "annealed" with the substance in a computer simulation. This shows the optimum ratios of template substance to individual monomers. An appropriate mixture of monomers is then polymerised in the presence of the template to produce a MIP.

Description

[0001] The present invention relates to methods and means for use in the preparation of molecularly imprinted polymers ("MIPs"), to the MIPs that can be created using them, and to applications of the MIPs.[0002] The present invention particularly relates to an application of computer-aided rational design techniques for the rapid development and optimization of polymers that act as synthetic receptors. Specifically the imprinted polymers are synthesized by a polymerization of individual monomers with or without cross-linker in the presence of template molecule(s), which can be small molecules such as drugs, pesticides, peptides as well as large molecules such as carbohydrates, nucleic acids and proteins.[0003] Molecularly imprinted polymers (MIPs), materials with artificially created receptor-like recognition properties, have recently attracted significant attention as potential substitutes for unstable receptors and antibodies in affinity chromatography, membranes, capillary electr...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C08F2/00C08F2/44C08F251/00C08F289/00C08F291/00C08G85/00C40B30/02C40B40/14C40B50/02
CPCC08F2/44C08F251/00G01N2600/00C08F291/00C08F289/00
Inventor CHEN, BEININGDAY, RICHARD MSUBRAHMANYAM, SREENATHPILEISKY, SERGIY APILEISKA, OLENA VTURNER, ANTHONY P F
Owner CRANFIELD UNIVERSITY
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