Double resonance interrogation of grating-coupled waveguides

Inactive Publication Date: 2005-03-31
CORNING INC
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  • Summary
  • Abstract
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Problems solved by technology

While there are many approaches for accomplishing these tasks, each has unique challenges associated with implementation, since the light beam output from the GCW sensor may be relatively weak and the presence of multiple sources of noise can degrade the light beam, especially in high-throughput screening applications.
Since the resonance condition of the GCW sensor is critically dependent on the angle of the light striking the microplat

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  • Double resonance interrogation of grating-coupled waveguides
  • Double resonance interrogation of grating-coupled waveguides
  • Double resonance interrogation of grating-coupled waveguides

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Section I—Definitions

Before describing the present invention in detail, this invention is not necessarily limited to specific compositions, reagents, process steps, or equipment, as such may vary. As used in this specification and the appended claims, the singular forms “a,”“an,” and “the” include plural referents unless the context clearly dictates otherwise. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting. All technical and scientific terms used herein have the usual meaning conventionally understood by persons skilled in the art to which this invention pertains, unless context defines otherwise.

The term “air-fluid delivery system” as used herein refers to a fluidic (i.e., gaseous or liquid) system that can collect samples of biological or chemical analytes from the atmosphere or surrounding environs, and deliver the samples to a sensor.

The term “analyte” or “target”...

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Abstract

A method for using a double resonance effect within a grating-coupled waveguide (GCW) sensor, as generated from a light beam with a given span of wavelengths or angles, is provided. The method can be used for label-independent detection of biological and chemical agents, to interrogate biological-binding events or chemical reactions within a sensing region at increased sensitivity, and with decreased sensitivity to environmental perturbations. Also described is an optical interrogation system incorporating the method.

Description

FIELD OF INVENTION The present invention pertains in general to a sensor used for label-independent detection of biological and chemical agents. More particularly, the invention relates to 1) a method for using a double resonance effect within a grating-coupled waveguide (GCW) sensor, as generated from a light beam with a given span of wavelengths or angles, to interrogate biological-binding events or chemical reactions within a sensing region at increased sensitivity, and with decreased sensitivity to environmental perturbations, and 2) an optical interrogation system incorporating the method. BACKGROUND Evanescent field-based sensors are fast becoming a technology of choice for accurate label-free detection of a biological, biochemical, or chemical substance (e.g., cells, spores, biological or drug molecules, or chemical compounds). This technology typically involves using a grating-coupled waveguide (GCW) to sense a concentration change, surface adsorption, reaction, or the mer...

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Application Information

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IPC IPC(8): G01N21/55
CPCG01N21/7743Y10S436/805
Inventor GOLLIER, JACQUESMOZDY, ERIC J.PIECH, GARRETT A.
Owner CORNING INC
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