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Optical measuring device for substances in vivo

Inactive Publication Date: 2006-02-02
HITACHI LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0010] In order to solve this problem, a device is comprised of means to irradiate the living body to be checked with a light, means to detect the resultant transmitted or reflected light, means to apply a magnetic field to lights passing the living body in a direction crossing the position of irradiation with light and the position of detecting the light, and means to analyze the polarization of the detected light, whereby the Faraday rotation angle α is measured, from which the glucose concentration is bloodlessly determined. If a plurality of independent lights differing in wavelength are used in this process, the glucose concentration can be measured even more accurately.

Problems solved by technology

A blood sample would allow measurement of the glucose concentration by the enzyme electrode method or otherwise, but taking a blood sample causes pain to the patient.

Method used

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  • Optical measuring device for substances in vivo
  • Optical measuring device for substances in vivo
  • Optical measuring device for substances in vivo

Examples

Experimental program
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embodiment 1

(Embodiment 1)

[0029] A first preferred embodiment of the present invention will be described with reference to FIG. 1. FIG. 1 is a block diagram illustrating the principle of a transmission type concentration measuring device for substances in vivo using Faraday effect. Reference numerals 101 through 105 denote laser diodes of 780 nm, 830 nm, 870 nm, 1300 nm and 1500 nm, respectively, in wavelength.

[0030] The laser diodes are amplitude-modulated with different frequencies fi, respectively 10 kHz, 12 kHz, 14 kHz, 16 kHz and 18 kHz, for example. Reference numeral 111 denotes a lens and 112, a polarizer. The laser diodes 101 through 105, the lens 111 and the polarizer 112 constitute a light source system 110.

[0031] The output lights of the laser diodes 101 through 105 are collimated by using the lens 111 and, after passing the polarizer 112, irradiate an object region (e.g. a finger) 113. The lights having passed the object region 113, after being collimated by a lens 121, are guided...

embodiment 2

(Embodiment 2)

[0035] A second preferred embodiment of the invention will now be described with reference to FIG. 2. FIG. 2 is a block diagram illustrating the principle of a reflection type concentration measuring device for substances in vivo using Faraday effect. While the arrangement of Embodiment 1 is to let lights pass the object region, this second embodiment uses a reflection type arrangement. The hardware configuration is almost the same as that of Embodiment 1. The light source system 110 and the detector system 120 are arranged on the same side with respect to the object region 113. Incidentally, the light source system 110 and the detector system 120 are the same as their respective counterparts in FIG. 1. The focal position of the lens 111 and that of the lens 121 may be the same, but deviating one from the other would increase the contribution of blood vessels within the epidermis to signals. For this reason, the distance between the focal positions of the two lenses he...

embodiment 3

(Embodiment 3)

[0039] A third preferred embodiment of the invention will be described with reference to FIG. 3. FIG. 3 is a block diagram illustrating the interfering effect of low-coherence light sources and the principle of a concentration measuring device for substances in vivo using the effect of interference by low-coherence light sources and Faraday effect. The output lights of super-luminescent diodes 301, 302 and 303 of 840 nm, 1310 nm and 1550 nm in wavelength, after being let pass a half mirror 320 and a polarizer 111, are focuses on the surface of the object, for instance the surface of a finger 113, by using a lens 112. The reflected lights from the surface of the finger 113 are again collimated by the lens 112 and, after passing the polarizer 111, are reflected by the half mirror 320 to come into incidence on the photodiode 123. On the other hand, part of the lights emitted from the super-luminescent diodes 301 through 303 is separated by the half mirror 320, reflected b...

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Abstract

In order to provide a compact device easy to handle and adjust for use in bloodless measurement of the glucose concentration, in which the angle of polarization varies in synchronism with the magnetic field modulation, the direction of applying the magnetic field is so arranged as to cross the optical axis.

Description

CLAIM OF PRIORITY [0001] The present application claims priority from Japanese application JP 2004-225166 filed on Aug. 2, 2004, the content of which is hereby incorporated by reference into this application. FIELD OF THE INVENTION [0002] The present invention relates to noninvasive and bloodless measurement of the concentrations of substances, especially that of glucose, in vivo by using light rays, and more particularly to a glucose sensor and a glucose monitor. BACKGROUND OF THE INVENTION [0003] Diabetes patients have to receive regular checkup of the glucose concentration in blood for blood sugar control. A blood sample would allow measurement of the glucose concentration by the enzyme electrode method or otherwise, but taking a blood sample causes pain to the patient. For this reason, development of a bloodless measuring device which requires no blood sampling is called for. [0004] On the other hand, a glucose sensor using Faraday effect is disclosed in Patent Reference 1. This...

Claims

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Application Information

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IPC IPC(8): A61B5/00
CPCA61B5/14558A61B5/14532
Inventor KIGUCHI, MASASHITOMARU, TATSUYAKOIZUMI, HIDEAKIMAKI, ATSUSHIKAWAGUCHI, HIDEO
Owner HITACHI LTD
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