Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles

Inactive Publication Date: 2006-03-23
WANG MARK M +8
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Benefits of technology

[0033] Yet another object of this invention is to provide a system in which particles may be manipulated remotely, thereby reducing the contamination to the system under study.
[0034] It is yet another object o

Problems solved by technology

Existing technologies cannot efficiently and comprehensi

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  • Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
  • Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
  • Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles

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Definitions

[0075] The following definitions are provided for an understanding of the invention disclosed herein.

[0076]“Dielectric constant” is defined to be that property which determines the electrostatic energy stored per unit volume for unit potential gradient. (See, e.g., the New IEEE Standard Dictionary Of Electrical And Electronics Terms,© 1993).

[0077] The “optical dielectric constant” is the dielectric constant of a particle or thing at optical wavelengths. Generally, the optical wavelength range is from 150 Å to 30,000 Å.

[0078] An “optical gradient field” is an optical pattern having a variation in one or more parameters including intensity, wavelength or frequency, phase, polarization or other parameters relating to the optical energy. When generated by an interferometer, an optical gradient field or pattern may also be called an optical fringe field or fringe pattern, or variants thereof.

[0079] A “moving optical gradient field” is an optical gradient field that moves...

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Abstract

Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a particle may be characterized by determining its optophoretic constant or signature. For example, a diseased cell has a different optophoretic constant from a healthy cell, thereby providing information, or the basis for sorting. In the event of physical sorting, various forces may be used for separation, including fluidic forces, such as through the use of laminar flow, or optical forces, or mechanical forces, such as through adhesion. Various techniques for measuring the dielectric constant of particles are provided.

Description

RELATED APPLICATIONS [0001] This application is a continuation of U.S. application Ser. No. 09 / 845,245, filed Apr. 27, 2001, entitled “Methods and Apparatus for Use of Optical Forces for Identification, Characterization and / or Sorting of Particles”, and is related to application Ser. No. 09 / 843,902, filed on Apr. 27, 2001, entitled “System and Method for Separating Micro-Particles”, with named inventor Osman Kibar, which claims priority from provisional Application Ser. No. 60 / 248,451, entitled “Method and Apparatus for Sorting Cells or Particles”, filed Nov. 13, 2000. Those applications are incorporated herein by reference as if fully set forth herein.FIELD OF THE INVENTION [0002] This invention relates to methods and apparatus for the selection, identification, characterization, and / or sorting of materials utilizing at least optical or photonic forces. More particularly, the inventions find utility in biological systems, generally considered to be the use of optical forces for int...

Claims

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Application Information

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IPC IPC(8): H05H3/02G01N15/00B07C5/34C12Q1/04G01N15/14G01N30/02G21K1/00
CPCB07C5/34G01N15/1459G01N15/1463G01N30/02G01N2015/1486H05H3/04G01N2015/149B01D2015/3895
Inventor WANG, MARK M.TU, EUGENEPESTANA, LUIS M.SENYEI, ANDREW E.O'CONNELL, JAMES P.NOVA, TINA S.LYKSTAD, KRISTIE L.HALL, JEFFREY M.BUTLER, WILLIAM F.
Owner WANG MARK M
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