Cell membrane translocation of regulated snare inhibitors, compositions therefor, and methods for treatment of disease

a cell membrane and inhibitor technology, applied in the direction of anti-antibody medical ingredients, peptide/protein ingredients, therapy, etc., can solve the problems of affecting the treatment effect of patients, affecting the treatment effect, and few amphipathic protein conjugates currently approved
US20060153876A1Inactive Publication Date: 2006-07-13SANDERS
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Patent Information

Authority / Receiving Office
US ¡ United States
Patent Type
Applications(United States)
Current Assignee / Owner
SANDERS
Publication Date
2006-07-13
Estimated Expiration
Not applicable ¡ inactive patent
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Abstract

Compositions and methods of modulating cellular function and treatment of disease in mammals comprising locally administering a regulated SNARE inhibitor and a translocating agent to the mammal. Regulated SNARE inhibitors include clostridial neurotoxins, tetanus neurotoxin and their free light chain portions and IgA protease. Translocating agents include acids, encapsulating vectors, and transduction domains.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of International Application No. PCT / US04 / 05436, filed Feb. 24, 2004, entitled Cell Membrane Translocation of Regulated Snare Inhibitors, Compositions Therefor, and Methods for Treatment of Disease; and U.S. Provisional Application No. 60 / 449,107 filed Feb. 24, 2003, entitled Compositions of Amphipathic Pharmaceuticals and Methods For Their Use, by I. Sanders, which applications are hereby incorporated herein by reference in their entirety.FIELD OF THE INVENTION

[0002] This invention relates to translocation of bioactive molecules through cell membranes. More specifically, the invention relates to cell membrane translocation of regulated SNARE inhibitors, compositions and formulations thereof, and methods for treatment of disease. BACKGROUND OF THE INVENTION

[0003] A promising area of pharmaceutical intervention is the use of macromolecules that act within cells. These include gene therapy, natural an...

Claims

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