Fluid processing device comprising surface tension controlled valve

Abstract

A fluid processing device adapted to produce different oligomers in a plurality of respective reaction sites and methods of using the same are provided. The fluid processing device can comprise a first manifold for delivering reactants to the plurality of reaction sites, and a second manifold for removing waste from, and optionally delivering wash fluid to, the plurality of reaction sites. Surface tension controlled valves can be disposed in fluid communication with the first manifold, the second manifold, or both, and can selectively allow reactants and / or fluids into the reaction sites. A method of making oligonucleotides is also provided.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation-in-part of U.S. patent application Ser. No. 11 / 092,180 filed on Mar. 29, 2005, and claims the benefit under 35 U.S.C. § 119(e) of Provisional Application No. 60 / 642,828 filed on Jan. 11, 2005, each of which is incorporated herein by reference in its entirety.FIELD [0002] The present teachings relate to valves in fluid processing devices, and methods for using the same. INTRODUCTION [0003] One of the challenges encountered in fluid processing devices, particularly devices designed for high throughput operations, is how to effectively control fluid flow. A need exists to individually and independently control fluid flow in thousands of micro-channels without resorting to the fabrication of sophisticated valving systems that can make microfluidic devices very expensive. SUMMARY [0004] According to various embodiments, a device and method for controlling fluid flow in a microfluidic system is provided. In ...

AI Technical Summary

Benefits of technology

The patent describes a device and method for controlling fluid flow in a microfluidic system. The device includes a valve controlled by surface tension, which can be activated by light to reduce resistance to the flow of biological fluid. The device can also include a means for providing the biological fluid to the valving means, such as a means for electrowetting or optical activation. The method can be used for synthesizing oligonucleotides or other chemical structures by introducing monomers into a fluid distribution manifold and using the surface tension control valve to form extended structures. The technical effects of the invention include improved control over fluid flow and reduced resistance to the flow of biological fluid.

Problems solved by technology

One of the challenges encountered in fluid processing devices, particularly devices designed for high throughput operations, is how to effectively control fluid flow.

The means for providing the biological fluid can be non-resistant to the flow of the biological liquid.

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