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Microbial cellulose materials for use in transdermal drug delivery systems, method of manufacture and use

a technology of microbial cellulose and transdermal drug delivery, which is applied in the field of polysaccharide materials, can solve the problems of unrecognized skin, unrecognized skin, and no method previously described suggests creating a highly hydrated environmen

Inactive Publication Date: 2006-10-26
XYLOS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of the methods previously described suggests creating a highly hydrated environment by using hydrated microbial cellulose sheets to deliver drugs and active agents.
However, the ability of highly hydrated sheets of microbial cellulose to promote the creation of such aqueous channels, pores or reduced tortuosity on intact skin has not been disclosed previously.

Method used

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  • Microbial cellulose materials for use in transdermal drug delivery systems, method of manufacture and use
  • Microbial cellulose materials for use in transdermal drug delivery systems, method of manufacture and use

Examples

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example 1

Delivery of Antibiotics

[0054] In cases of difficult to heal wounds, clinicians believe that there may be microbial colonization that has not reached levels of infection. Depending on the type of microbe (gram negative or gram positive bacteria, fungus, etc) a specific treatment is optimal. Patients having wounds that were no longer responsive to treatment were evaluated for colonization. Those with gram-positive bacteria were treated with microbial cellulose that had been soaked in a solution of vancomycin. Dressings were changed as needed. Results indicated that the vancomycin treated wounds improved and went on to heal in an average of five weeks. Serum trough levels of the antibiotics (values of the amount of an antibiotic that has passed through the skin and into the blood) demonstrated a profound local effect. Minute quantities of vancomycin were noted in the circulatory system. This demonstrated the delivery of antibiotics by microbial cellulose.

example 2

Delivery of Lidocaine by Microbial Cellulose

[0055] A solution of 4% lidocaine was added to microbial cellulose and allowed to soak into the microbial cellulose for 5 minutes. This was then placed onto the patient's wound for 5 to 15 minutes prior to sharp debridement of necrotic tissue. Delivery of the lidocaine through the thick layer of dry necrotic tissue was evidenced by the lack of pain that the patient felt during the debridement process. A similar study performed on intact skin demonstrated that lidocaine was released over a 7-day period to relieve pain administered by a sharp object.

example 3

Delivery of Thrombin by Microbial Cellulose

[0056] Thrombin was reconstituted per instructions for use and applied to microbial cellulose for 5 minutes. The dressing containing the thrombin solution was applied to a patient that had excessive diffuse bleeding after sharp debridement and was removed after 24 hours. The combination of thrombin and microbial cellulose effectively established hemostasis.

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Abstract

A method for transdermally delivering a biologically active agent to a subject in need thereof, comprising topically applying a composition comprising insoluble microbial cellulose, water, and a therapeutically effective amount of the biologically active agent, wherein the biologically active agent penetrates through the subject's stratum corneum at a substantially constant rate.

Description

FIELD OF INVENTION [0001] This invention relates to polysaccharide materials and more particularly to microbial cellulose for use in transdermal drug delivery systems. The invention also relates to the use of microbial cellulose and microbial cellulose composites containing various agents as transdermal drug delivery devices and to the methods of producing and using such materials. BACKGROUND [0002] One of the functions of skin is to protect the body from aqueous, biological, chemical, and mechanical assault. To achieve this, the outermost layer, called the epidermis, ranges from 75 to 600 microns in thickness and contains cells that limit the permeability of various low and high molecular weight active agents. It is also avascular such that any active agent must pass through the skin to reach the dermis before it can enter the bloodstream and have a systemic effect. [0003] Various physical and chemical means have been used to enhance delivery of drugs and active agents by creating ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/14A61K31/7034A61K38/48A61K31/496A61F13/02A61K31/24A61K31/4178
CPCA61K9/0014A61K9/70A61K9/7007A61K9/7023A61K31/167A61K31/24A61K38/4833A61K31/496A61K31/7034A61K31/7036A61K38/14A61K38/28A61K31/4178
Inventor SERAFICA, GONZALOMINK, RICHARDHOON, RUSSELLDAMIEN, CHRISTOPHER
Owner XYLOS CORP
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