Therapeutic applications of pro-apoptotic benzodiazepines

a technology of pro-apoptotic benzodiazepines and therapeutic applications, applied in the field of medicinal chemistry, can solve the problems of difficult treatment of ovarian cancer, pathologic accumulation of t and b cells,
US20070036854A1Inactive Publication Date: 2007-02-15RGT UNIV OF MICHIGAN
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
RGT UNIV OF MICHIGAN
Publication Date
2007-02-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

Benzodiazepine compounds, and methods for using those compounds are provided. Some of the benzodiazepine compounds include 1,4-benzodiazepine-2-one and 1,4-benzodiazepine-2,5-dione compounds of the following structures: wherein R1, R2, R3 and R4 are as defined. The invention also includes enantiomers, pharmaceutically acceptable salts, prodrugs or derivatives of the benzodiazepine compounds. Any one or more of these benzodiazepine compounds can be used to treat a variety of dysregulatory disorders related to cellular death. Such disorders include autoimmune disorders, inflammatory conditions, hyperproliferative conditions, viral infections, and atherosclerosis. In addition, the above compounds can be used to prepare medicaments to treat the above-described dysregulatory disorders. The benzodiazepines can also be used in drug screening assays and other diagnostic methods.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] The present disclosure claims priority to U.S. Provisional Application Nos. 60 / 191,855, filed Mar. 24, 2000; 60 / 131,761, filed Apr. 30, 1999; and 60 / 165,511, filed Nov. 15, 1999, the contents of which are hereby incorporated by reference.FIELD OF THE INVENTION

[0002] The present invention is in the field of medicinal chemistry and relates to other areas such as pharmacology, biochemistry and organic chemistry. In particular, it provides novel chemical compounds, and their therapeutic uses. BACKGROUND

[0003] Multicellular organisms exert precise control over cell number. The normal structure and function of tissues depends on the maintenance of appropriate cell numbers. A balance between cell proliferation and cell death (White, E. (1996) Genes Dev. 10:1-15) achieves this homeostasis.

[0004] Cell death occurs in nearly every type of vertebrate cell via necrosis or through a suicidal form of cell death, known as apoptosis. Apoptosis is tr...

Claims

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