Powder mix of potassium calcium citrate for the treatment of kidney stones and osteoporosis

a potassium calcium citrate and kidney stone technology, applied in the direction of biocide, drug composition, sexual disorder, etc., can solve the problem of low risk of stone formation that might rise from calcium supplementation, and achieve the effect of chronic diarrheal syndrom

Inactive Publication Date: 2007-04-05
BOARD OF RGT THE UNIV OF TEXAS SYST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0015] In another aspect of the present invention there is a method of treating or preventing osteoporosis or kidney stones or both in an animal comprising the administration of a composition comprising a mixture of potassium citrate, citric acid and a component selected from the group consisting of calcium carbonate, calcium hydroxide, calcium oxide and any combination thereof, said composition having a molar ratio of potassium:calcium:citrate ranging from 2:1:1.33 to 2:1:2.67. Preferably, the animal to which the composition is administered is human. In those cases where the composition is administered to a human, the human is preferably a postmenopausal woman. In some embodiments, the administration comprises oral administration. In some embodiments, the animal to which the composition is administered has chronic diarrheal syndrome. Preferably, the composition has a molar ratio of potassium:calcium:citrate of 2:1:1.33.
[0016] In another aspect of the present invention, there is a method of treating or preventing osteoporosis or kidney stones or both in an animal comprising the administration of a composition comprising a mixture of potassium citrate and calcium citrate having a molar ratio of potassium:calcium:citrate ranging from 2:1:1.33 to 2:1:2.67. Preferably, the animal to which the composition is administered is human. In those cases where the composition is administered to a human, the human is preferably a postmenopausal woman. In some embodiments, the administration comprises oral administration. In some embodiments, the animal has chronic diarrheal syndrome.

Problems solved by technology

Moreover, calcium citrate supplementation modestly increases urinary citrate, an inhibitor of kidney stone formation; thus, the risk of stone formation that might rise from calcium supplementation is thought to be low from this supplementation.

Method used

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  • Powder mix of potassium calcium citrate for the treatment of kidney stones and osteoporosis
  • Powder mix of potassium calcium citrate for the treatment of kidney stones and osteoporosis
  • Powder mix of potassium calcium citrate for the treatment of kidney stones and osteoporosis

Examples

Experimental program
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Effect test

example 1

[0034] Metabolic Studies on Prevention of Kidney Stone Formation

[0035] A total of eighteen postmenopausal women without kidney stones underwent four phases of study chosen in random order while they were kept on a constant diet in a metabolic ward. Lasting two weeks each, the four phases comprised: potassium citrate (Urocit-K®) 20 mEq twice daily, calcium citrate (Citracal®) 400 mg calcium twice daily, both potassium citrate and calcium citrate at same dosages, and placebo. During last two days of each phase, urine was collected in 24-hour pools for biochemistry and stone risk factors. The combined treatment with potassium citrate and calcium citrate from this metabolic study is equivalent to treatment with potassium calcium citrate as embodied by this invention, since the amount of calcium and potassium conferred by combined treatment was about the same as the intended dose of the object of this invention.

[0036] Provision of Alkali Load.

[0037] The ability of calcium citrate and ...

example 2

[0045] Metabolic Studies on Preventing Bone Loss

[0046] In the same study involving the identical subjects described in Example 1, the effect on bone metabolism of potassium citrate, calcium citrate, and combination of the two was examined. During the last two days of each two-week phase, serum and 24-hour urine samples were collected for assessment of calcium metabolism, alkali load, and bone turnover markers.

[0047] Serum Calcium and Parathyroid Hormone.

[0048] Serum calcium and parathyroid hormone did not change with potassium citrate treatment (FIG. 5). Serum calcium increased slightly, and serum parathyroid hormone significantly decreased with calcium citrate. The combined treatment (resembling potassium calcium citrate) significantly increased serum calcium and marginally decreased serum parathyroid hormone.

[0049] Markers of Bone Turnover.

[0050] The effect of treatment on bone resorption (destruction) was evaluated from urinary hydroxyproline, urinary N-telopeptide, and seru...

example 3

[0054] Conditions Amenable to Treatment with Potassium Calcium Citrate

[0055] High Meat Diet.

[0056] The consumption of a high animal protein diet such as the Atkins' diet commonly taken for weight control, may increase the risk of kidney stones and bone loss. In a carefully conducted study in subjects consuming a constant diet, the Atkins' diet was shown to produce a marked acid load, nearly double urinary calcium, and lower urinary pH (making urine more acid) and citrate (inhibitor of calcium stone formation) (Reddy et al., 2002, Amer. J. Kid. Dis., 40: 265-274). Thus, the urine became more supersaturated with respect to stone-forming salts, making the formation of uric acid and calcium oxalate stones more likely. At the same time, the calcium balance turned more negative, because the intestinal calcium absorption was not changed even though urinary calcium increased.

[0057] Chronic Diarrheal Syndrome.

[0058] From the Stone Clinic of the inventors (CYCP and KS), 71 patients with c...

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Abstract

A composition comprising a powder mixture of potassium citrate and calcium citrate as mixtures of pure chemical salts and methods of making and using the composition are disclosed. The composition is useful for the treatment and prevention of kidney stones and osteoporosis and better delivers potassium and calcium than commonly used potassium and calcium supplements.

Description

TECHNICAL FIELD [0001] A method is presented for making a powder formulation of potassium calcium citrate as mixtures of pure chemical salts, to be dissolved before ingestion, the said formulation yielding identical amounts of potassium and calcium and the same or slight excess of citrate, as delivered by potassium citrate and calcium citrate at doses commonly prescribed for the treatment of kidney stones and osteoporosis. BACKGROUND OF THE INVENTION [0002] Mineral compositions are commonly taken as dietary aids, either as therapeutic preparations directed to a specific medical problem or as general nutritional supplements. Among useful dietary supplements are dosage units of calcium citrate, orally administered in solid or liquid form (U.S. Pat. Nos. 4,772,467, 4,814,177, and 4,851,221; each patent herein incorporated by reference). Oral administration of calcium citrate as a nutritional supplement both modestly increases levels of urinary citrate and provides bioavailable calcium....

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/19A61K33/10A61K33/08
CPCA61K31/19A61K33/08A61K33/10A61K2300/00A61P1/12A61P13/12A61P15/12A61P19/10
Inventor PAK, CHARLES Y.C.SAKHAEE, KHASHAYARWALSDORF, NEILL B. SR.
Owner BOARD OF RGT THE UNIV OF TEXAS SYST
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