Method and device for decoupling and/or desynchronizing neural brain activity

a neural brain activity and brain activity technology, applied in artificial respiration, therapy, application, etc., can solve the problem that the effective mechanism on which the standard depth stimulation is based has not been explained sufficiently

Active Publication Date: 2007-08-30
NEMOTEC UG HAFTUNGSBESCHRANKT
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0013] The device according to the invention enables the effect achieved intraoperatively by means of the decoupling stimulation to be used for selecting the most suitable target point for the electrode. When using a depth brain electrode as electrode 2, a test stimulus and/or derivation of the feedback signal is first carried out in mm steps with the device according to the invention in the area of the anatomically precalculated target point during the implantation of the electrode. The target point at which the best therapeutic effect can be achieved is selected as target point for the perman

Problems solved by technology

In this case, a large number of neurons form synchronous action potentials; the neurons involved are firing excessively syn

Method used

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  • Method and device for decoupling and/or desynchronizing neural brain activity
  • Method and device for decoupling and/or desynchronizing neural brain activity
  • Method and device for decoupling and/or desynchronizing neural brain activity

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Embodiment Construction

[0031] Reference will now be made in detail to the embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the like elements throughout. The embodiments are described below to explain the present invention by referring to the figures.

[0032] In FIGS. 2a to d and 3a to d, the abscissa designate the time axes in seconds whereas along the ordinates, the measured neural activity (FIGS. 2a, 3a) or the firing pattern (FIG. 2b, 3b) or the extent of synchronization (FIG. 2c, 3c) or the sum of the coupling and stimulation influences (FIG. 2d, 3d) are in each case plotted in arbitrary units. The neural activity measured via sensors 3 (FIG. 2a, 3a) is used as the basis for generating the stimulation stimulus. In FIGS. 2e and 3e, the abscissa designates the frequency and the ordinates designate the relative number of neurons with the corresponding frequency.

[0033] The device according to FIG. 1 comprises an ...

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Abstract

A device for decoupling and/or desynchronizing neural, pathologically synchronous brain activity, in which, the activities in a partial region of a brain area or a functionally associated brain area are stimulated by means of an electrode, resulting in decoupling and desynchronizing the affected neuron population from the pathological area and suppression of the symptoms in a patient. In an alternative embodiment of the device, the pathologically synchronous brain activity due to the disease is desynchronized which also leads to the symptoms being suppressed. The device has a stimulation electrode and at least one sensor which are driven by a control system in such a manner that they produce decoupling and/or desynchronization in their local environment.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuing application, filed under 35 U.S.C. §111(a), of International Application PCT / DE2005 / 000780, filed on Apr. 28, 2005, it being further noted that priority is based upon German Patent Application 10 2004 025 945.3, filed on May 27, 2004, the contents of which are incorporated herein by reference.BACKGROUND OF THE INVENTION [0002] The invention relates to a device for decoupling and / or desynchronizing neural brain activity. SUMMARY OF THE INVENTION [0003] Additional aspects and / or advantages of the invention will be set forth in part in the description which follows and, in part, will be apparent from the description, or may be learned by practice of the invention. [0004] A pathologically synchronous brain activity which can have its origin, for example, in the basal ganglia, can also produce synchronization in the following areas such as, for example, the motor cortex, as a driving force. This secondary syn...

Claims

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Application Information

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IPC IPC(8): A61N1/18A61B5/00A61B5/374A61N1/05A61N1/36
CPCA61B5/0006A61B5/048A61B5/7225A61B5/726A61N1/36146A61N1/06A61N1/36067A61N1/36082A61N1/36135A61N1/0551A61B5/4082A61B5/374
Inventor TASS, PETERPOPOVYCH, OLEKSANDRHAUPTMANN, CHRISTIANKRACHKOVSKYI, VALERIL
Owner NEMOTEC UG HAFTUNGSBESCHRANKT
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