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Composition for topical substance delivery

a topical substance and composition technology, applied in the direction of aerosol delivery, antibacterial agents, metabolism disorders, etc., can solve the problems of increasing tooth decay, unable to provide the dual function of both delivering fluids, and generally lacking hydrodynamic properties of compositions used for topical medicament delivery. to achieve the effect of resisting cracking, tearing and crumbling, and increasing the polymerization efficiency of hydrogel compositions

Inactive Publication Date: 2007-10-11
SOLUBLE SYST LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is about a hydrogel composition that can hydrate or dehydrate surfaces. It is made up of two polymerizable materials, a polymerization catalyst, and a polymerization medium. The composition can release consistent amounts of moisture over a long period of time or absorb moisture from a surface. The method for making the composition involves mixing the materials together and adding a redox catalyst system. The composition can be used as a wound dressing, in implanted therapy, and for managing dry eyes. It has controllable moisture release and absorption rates, is resistant to cracking, tearing, and crumbling, and can be infused with a humectant to increase efficiency of polymerization.

Problems solved by technology

Not only is this affliction irritating, it can also aggravate problems involving swallowing and speaking and may even lead to increased tooth decay.
In the elderly xerostomia is particular dangerous since it may interfere with eating and result in malnutrition.
Furthermore, although it is known to have syringe applicators or encapsulated sponges for delivering medicaments or moisture, compositions used for the purpose of topical delivery of medicament generally do not typically exhibit any hydrodynamic properties which would enhance their delivery capability.
Moreover, such compositions cannot provide the dual function of both delivering fluids to and removing them from a chosen site as desired.
First, the delivery system must be biocompatible since it can be used inside body cavities such as the mouth or elsewhere in direct contact with the skin.
This point is particularly important since, due to dryness, the mouth may be prone to infection and is likely to be highly sensitive.

Method used

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  • Composition for topical substance delivery
  • Composition for topical substance delivery
  • Composition for topical substance delivery

Examples

Experimental program
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Embodiment Construction

[0027] The moisture delivery and removal system of this invention is comprised of a composition used to absorb, retain and release medicaments and / or fluids. Table 1 identifies each element in the composition, the approximate percentage of the whole by weight which that element represents in any given amount of composition prior to initiation of the chemical reaction resulting in formation of the composition. A more detailed description of each element and its affect on the composition follows Table 1.

TABLE 1ElementPreferred % by weightRange % by weightHEMA26.226-35EGDMA1.3  1-1.8AP.40.3-0.5TEMED.20.1-0.3Distilled water65.462-72IPA6.5 0-11Total100.0

[0028] The composition includes two polymerizable materials. The main polymer is 2-hydroxyethyl methacrylate, or HEMA. It is easily polymerized using thermally activated free radical initiators, i.e. 2,2′-azobisisobutyronitrile (AIBN), or redox catalyst systems. The monomer is water-soluble and the resulting polymer is very hydrophilic ...

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Abstract

A polymerized hydrogel composition for hydrating or dehydrating a surface, particularly a dermatological surface, to which it is applied and a method for forming the composition. The composition is comprised of a mixture of two polymerizable materials, a two-part redox catalyst system and a two-part polymerization medium. The percentage by weight of each element in the composition may be varied within stated percentage ranges and depending to the desired application. The rate at which hydration or dehydration occurs may be controllably altered by varying the percentages of certain of the composition elements and by adding either or both of a fibrous filler material and a humectant to the composition.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS [0001] This application is a continuation-in-part of U.S. application Ser. No. 09 / 580,679, filed on May 30, 2000, also filed as PCT / US01 / 15462 on May 11, 2001.TECHNICAL FIELD [0002] The subject invention relates generally to the delivery of moisture to and removal of moisture from a dermatological surface, and, more particularly, to a composition for providing soluble medicaments and moisture to such surfaces. BACKGROUND OF THE INVENTION [0003] The ability to provide a controlled, variable release of soluble medicaments or aqueous substances in a topical manner is desirable for treating a variety of diseases and ailments. For example, the general aging of the population is accompanied by a concomitant increase in the number of cases of dry mouth, also referred to as xerostomia. This is a condition in which salivary flow is either decreased or undergoes a compositional change. Not only is this affliction irritating, it can also aggravate probl...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/10A61K9/06A61K9/00A61K9/70A61K47/32A61L26/00A61P1/02A61P3/10A61P5/00A61P17/02A61P17/16A61P19/02A61P25/24A61P27/04A61P29/00A61P31/04A61P31/18A61P39/02C08F20/18C08F220/28
CPCA61K9/0014A61K9/0048A61K9/06A61K47/32A61L26/0014C08F220/28A61L26/008C08L33/14A61P1/00A61P1/02A61P3/10A61P5/00A61P17/02A61P17/16A61P19/02A61P21/02A61P25/24A61P27/04A61P29/00A61P31/04A61P31/18A61P39/02C08F220/20
Inventor LEVY, GUY GLICKSONSTALEY, ALLAN RICHARDRANCOURT, JAMES DAVID
Owner SOLUBLE SYST LLC
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