Circulating mRNA as diagnostic markers

a technology of mrna and diagnostic markers, which is applied in the direction of microbiological testing/measurement, biochemistry apparatus and processes, etc., can solve the problems of limited application of this technology, increased complexity of fetal dna-based analysis, and invasive conventional methods, so as to increase the risk of developing, increase the amount of mrna, and increase the level of mrna
US20080153090A1Inactive Publication Date: 2008-06-26THE CHINESE UNIVERSITY OF HONG KONG
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
THE CHINESE UNIVERSITY OF HONG KONG
Publication Date
2008-06-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods and kits are provided for diagnosing, monitoring, or predicting the conditions of pre-eclaimpsia, fetal chromosomal aneuploidy, and pre-term labor in a pregnant woman, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more mRNA species encoding human chorionic gonadotropin β subunit (hCG-β), human placental lactogen (hPL), human corticotropin releasing hormone (hCRH), KiSS-1 metastasis-suppressor (KISS1), tissue factor pathway inhibitor 2 (TPFI2), placenta-specific 1 (PLAC1), or glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and comparing the amount of the mRNA species with a standard control.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional of U.S. application Ser. No. 10 / 759,783, filed Jan. 16, 2004. This application also claims priority to U.S. Provisional Application No. 60 / 440,906, filed Jan. 17, 2003, the contents of both are incorporated herein by reference in their entirety.BACKGROUND OF THE INVENTION

[0002] Prenatal diagnosis has been routinely conducted using cells isolated from the fetus through procedures such as chorionic villus sampling (CVS) or amniocentesis. These conventional methods are, however, invasive and present an appreciable risk to both the mother and the fetus despite most careful handling (Tabor et al., Lancet 1:1287-1293, 1986).

[0003] Alternatives to these invasive approaches have been developed for prenatal screening, e.g., to detecting fetal abnormalities, following the discoveries that several types of fetal cells can be found in maternal circulation (Johansen et al., Prenat. Diagn. 15:921-931, 1995) and more impor...

Claims

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