Fumagillol derivatives or method for preparation of fumagillol derivatives, and pharmaceutical compositions comprising the same

a technology of fumagillol and derivatives, which is applied in the field of fumagillol derivatives, can solve the problems of chemical stability, toxicity, and few possibilities of tolerance occurring, and achieve the effects of improving toxicity and chemical stability
US20100056623A1Inactive Publication Date: 2010-03-04CHONG KUN DANG PHARMA CORP
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
CHONG KUN DANG PHARMA CORP
Publication Date
2010-03-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a fumagillol derivative, pharmaceutically acceptable salts thereof and a method for preparing the same. The compounds of the present invention can be prepared through acylation, hydrolysis and alkylation. The compound of the present invention can be prepared in the form of a pharmaceutically acceptable salt or inclusion compound. The present invention provides fumagillol derivatives having the following characteristics: increased inhibiting effect on angiogenesis, low toxicity, excellent solubility and chemical stability as compared to conventional angiogenesis inhibitors. The compounds of the present invention can be used as an anti-cancer medicine, inhibitor of cancer metastasis, or the therapeutic agent for treating rheumatic arthritis, psoriasis, diabetic retinitis or obesity.
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Description

TECHNICAL FIELD

[0001] The present invention relates to a fumagillol derivative or a method for preparation thereof, and pharmaceutical compositions comprising the same.BACKGROUND ART

[0002] Angiogenesis is a phenomenon of generating new capillary vessels, which is one of the pathological phenomena happened in various diseases as well as one of normal physiological actions.

[0003] Additionally, Angiogenesis has a deep connection with growth and metastasis of solid cancer, rheumatic arthritis, diabetic retinopathy, psoriasis, or the like [Billington, D.C. Drug Design and Discovery, (1991), 8, 3.], and the compounds inhibiting angiogenesis show the effect of treatment for obesity [J. Folkman, PNAS, (2002), 99, 10730˜10735].

[0004] The compounds inhibiting angiogenesis have been developed and reported through many researches. Recently, as the clinical importance of therapeutic agents by means of controlling angiogenesis has been emphasized, researches on angiogenesis have increased. According ...

Claims

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