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Chimeric flavivirus vaccines

a technology of chimeric flavivirus and vaccine, applied in the field of attenuated viruses and infectious diseases, can solve the problems of japanese encephalitis, current or potential threats to global public health of several members of the flavivirus family,

Inactive Publication Date: 2010-11-04
SANOFI PASTEUR BIOLOGICS CO +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is about creating live viruses that can protect against flavivirus infections, such as yellow fever and dengue. These viruses are made by combining the genes and gene products of two different flaviviruses. The chimeric viruses have the advantage of being live and replicating, which can lead to long-lasting protective immunity. The invention also includes methods for preventing or treating flavivirus infections in humans by administering the chimeric viruses. Overall, the invention provides a way to create live viruses that can be used as vaccines against flavivirus infections.

Problems solved by technology

Several members of the flavivirus family pose current or potential threats to global public health.
For example, Japanese encephalitis is a significant public health problem involving millions of at risk individuals in the Far East.

Method used

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  • Chimeric flavivirus vaccines
  • Chimeric flavivirus vaccines
  • Chimeric flavivirus vaccines

Examples

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Embodiment Construction

[0056]The invention provides chimeric flaviviruses that can be used in vaccination methods against flavivirus infection. Construction and analysis of chimeric flaviviruses of the invention, such as chimeras of yellow fever virus and Japanese Encephalitis (JE), Dengue types 1-4 (DEN 1-4), Murray Valley Encephalitis (MVE), St. Louis Encephalitis (SLE), West Nile (WN), Tick-borne Encephalitis (TBE), and Hepatitis C (HCV) viruses are described as follows.

[0057]Yellow fever (YF) virus is a member of the Flaviviridae family of small, enveloped positive-strand RNA viruses. Flavivirus proteins are produced by translation of a single long open reading frame to generate a polyprotein, and a complex series of post-translational proteolytic cleavages of the polyprotein by a combination of host and viral proteases, to generate mature viral proteins (Amberg et al., J. Virol. 73:8083-8094, 1999; Fields, “Flaviviridae,” In Virology, Fields (ed.), Raven-Lippincott, New York, 1995, Volume I, p. 937)....

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Abstract

A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.

Description

[0001]This is a continuation of, and claims priority from, U.S. Ser. No. 12 / 423,566, filed Apr. 14, 2009 (abandoned), which is a continuation of U.S. Ser. No. 10 / 701,122, filed Nov. 4, 2003 (abandoned), which is a continuation of U.S. Ser. No. 09 / 452,638, filed Dec. 1, 1999 (U.S. Pat. No. 6,696,281), which is a continuation-in-part of U.S. Ser. No. 09 / 121,587, filed on Jul. 23, 1998 (U.S. Pat. No. 6,962,708), which is a continuation-in-part of PCT / US98 / 03894, filed on Mar. 2, 1998, which is a continuation-in-part of U.S. Ser. No. 09 / 007,664, filed on Jan. 15, 1998 (abandoned), which is a continuation-in-part of U.S. Ser. No. 08 / 807,445, filed on Feb. 28, 1997 (abandoned).BACKGROUND OF THE INVENTION[0002]This invention relates to infectious, attenuated viruses useful as vaccines against diseases caused by flaviviruses.[0003]Several members of the flavivirus family pose current or potential threats to global public health. For example, Japanese encephalitis is a significant public hea...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/12A61K39/29A61K39/00A61K38/21A61K38/20A61P35/00A61P31/14C12N7/01C07H21/04A61K39/193A61K48/00C07K14/18C12N7/04
CPCA61K35/13A61K39/29A61K39/12A61K39/193A61K48/00A61K2039/5254A61K2039/5256C07K14/005C07K2319/02C12N7/00C12N2770/24122C12N2770/24134C12N2770/24143C12N2770/24161C12N2770/24162A61K39/00A61P31/14A61P35/00Y02A50/30
Inventor CHAMBERS, THOMAS J.MONATH, THOMAS P.GUIRAKHOO, FARSHADARROYO, JUAN
Owner SANOFI PASTEUR BIOLOGICS CO
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