Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Treatment and prevention of deleterious effects associated with alcohol consumption

a technology of alcohol consumption and deleterious effects, applied in the direction of biocide, nervous disorder, drug composition, etc., can solve the problems of reducing the appearance of symptoms, reducing the effect of treatment, and reducing the effects of proposed treatments, so as to and prevent or reduce alcohol-induced flush reaction and hangover

Inactive Publication Date: 2012-01-26
TOKUNAGA RICHARD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

Famotidine effectively reduces immediate symptoms like redness, while succinic acid provides prolonged relief, effectively preventing or reducing hangover symptoms, with improved efficacy compared to traditional H2 antagonists like cimetidine.

Problems solved by technology

These polymorphisms frequently result in slowed conversion of acetaldehyde to acetic acid.
Such treatments do not address the conversion of alcohol to acetic acid but instead propose to competitively antagonize H1 and H2 histadine receptors while in circulation, which temporarily reduces the appearance of symptoms.
However, the proposed treatments suffer from two drawbacks.
First, many that suffer from alcohol-induced flush reaction do not respond to many of the proposed antagonists, which indicates the antagonists are not interchangeable.
Second, in some instances temporarily masking symptoms may lead to increased alcohol consumption, which may intensify deleterious effects once temporary relief ends.
Although alcohol-induced flush reaction is typically associated with redness that occurs relatively shortly after consumption of alcohol, the build up of acetaldehyde also contributes to hangover, which is often felt by many the morning after alcohol consumption.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Treatment and prevention of deleterious effects associated with alcohol consumption
  • Treatment and prevention of deleterious effects associated with alcohol consumption
  • Treatment and prevention of deleterious effects associated with alcohol consumption

Examples

Experimental program
Comparison scheme
Effect test

example 1

Prevention of Alcohol-Induced Flush Reaction in Subjects Treated with Famotidine

[0025]The following examples demonstrate the prevention or reduction of symptoms associated with alchohol-induced flush reaction. As control, each subject was tested without treatment. As a second control, each subject was treated with either loratidine (an H1 antagonist) or cimetidine (an H2 antogonist). Cimetidine is shown as FIG. 3A and loratidine is shown as FIG. 3B. Each subject was also treated with famotidine in a subsequent study. The results are summarized in tables 1-4 that follow.

Subject 1: Patent LB

[0026]Patient LB is a female, is 27 years old and weighs 115 lbs. She is not taking any medications presently. There is no other medical history of consequence.

[0027]Ms. LB drinks alcohol socially on occasion, usually in the form of Vodka. After imbibing several glasses of Vodka, however, LB consistently finds that she has a flushing of the face and torso. Via her own history and symptoms, Patient ...

example 2

Prevention of Alcohol Flush Reaction and Hangover by Administration of Famotidine and Succinic Acid

[0052]To test whether both alcohol flush reaction and hangover could be prevented, four subjects susceptible to both alcohol flush reaction and hangover were given a combination of famotidine and succinic acid prior to imbibing in alcohol. Previous studies with famotidine alone did not appear to significantly reduce or eliminate symptoms associated with hangover. Each subject was given 10 mg famotidine and 200 mg succinic acid prior to imbibing in alcohol. Afterwards each ingested sufficient alcohol that would ordinarily result in both flush reaction and hangover. None of the four tested individuals indicated flush symptoms or symptoms associated with hangover. Thus, the results show the combination of both famotidine and succinic acid prevents alcohol flush reaction and hangover.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides to methods and compositions that treat or prevent deleterious effects associated with alcohol consumption including alcohol-induced flush reaction and hangover. The methods and compositions include famotidine and optionally succinic acid. The present invention further demonstrates compositions that include famotidine are effective at treating symptoms associated with a flush reaction in subjects that are not significantly responsive to treatments with the H1 antagonist loratidine or the H2 antagonist cimetidine.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]The present invention is a divisional of U.S. patent application Ser. No. 12 / 323,098, filed Nov. 25, 2008 and is herein incorporated by reference in its entirety.TECHNICAL FIELD OF THE INVENTION[0002]The present invention relates to the prevention or treatment of effects associated with alcohol consumption and more specifically to methods and compositions for the treatment or prevention of alcohol-induced flush reaction and hangover.BACKGROUND OF THE INVENTION[0003]Metabolism of alcohol involves a two step enzymatic reaction. First, alcohol is oxidized to acetaldehyde by alcohol dehydrogenase. Second, the acetaldehyde is oxidized to acetic acid by acetaldehyde dehydrogenase and glutathione. Acetic acid is then transported to the muscles and adipose tissue where it is further broken down into carbon dioxide and water. Thus, the rate at which alcohol is metabolized to acetic acid depends in part upon the balance of both alcohol dehydrogenas...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/426A61P25/32
CPCA61K31/194A61K31/426A61K45/06A61K2300/00A61P25/32
Inventor TOKUNAGA, RICHARD
Owner TOKUNAGA RICHARD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com