Immune stimulating composition comprising an extract of aronia sp. in combination with selenium and/or zinc

a technology of aronia sp. and composition, which is applied in the direction of plant ingredients, biocide, plant growth regulators, etc., can solve problems such as weakened immune systems, and achieve the effect of increasing macrophage activity

Inactive Publication Date: 2012-06-14
URSAPHARM ARZNEIMITTEL
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0013]In the lines of extensive studies leading to the present invention the inventors have found that particular micronutrients, namely selenium, either alone or in combination with zinc, has an advantageous effect on the beneficial effects of Aronia extracts. It has been surprisingly found that an Aronia extract to which a particular amount of selenium or selenium and zinc has been added increases the macrophage activity by far in comparison to a composition merely containing a natural Aronia extract. The increased macrophage activity renders the present composition particularly suitable for the treatment of inflammatory diseases or conditions, bacterial infections, fungal infections, viral infections, parasitic infections.

Problems solved by technology

Selenium is known to be required for a proper activity of neutrophils, macrophages, NK cells, T lymphocytes and some other immune mechanisms and an insufficient supply of selenium to the human body may result in a weakened immune system.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Immune stimulating composition comprising an extract of aronia sp. in combination with selenium and/or zinc
  • Immune stimulating composition comprising an extract of aronia sp. in combination with selenium and/or zinc

Examples

Experimental program
Comparison scheme
Effect test

examples

Preparation of the Aronia Extract

[0078]Fresh-frozen Aronia fruits (chokeberries) have been used for preparing the Aronia extract (botanical species: Aronia melanocarpa). The aqueous pressed juice was concentrated to obtain a ratio of fruits to pressed juice concentrate (native) of 8-10 to 1.

Effect of the Aronia Extract and Aronia Extract with a Micronutrient on Macrophage Activity

[0079]Cells: Cell line (RAW 264.7, murine macrophages) was purchased from the America Type Culture Collection and cultivated as recommended.

[0080]Chemiluminescence Assay: Lucigenine (Sigma Chemicals Co.) was dissolved in Hank's Balanced Salt Solution (HBSS; Gibco Co.) at a concentration of 2×10−3 M. This stock solution was further diluted in HBSS prior to use. 1 ml cells (5×106 cells / ml) were incubated with 0.1 ml solution of Aronia extract and Aronia extract together with sodium selenite (dosis kinetics for each component and the combinations as documented in the figures). All these constituents were kept ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

It pertains to a composition which comprises a combination of Aronia extract in an amount of at least about 10 μg/mg and seleniumin in an amount from about 0.0001 μg/mg to about 2.0 μg/mg. The composition may further comprise zinc as additional micronutrient. The composition may be formulated as a pharmaceutical or a nutraceutical composition.

Description

[0001]The present invention relates to an immune stimulating agent, and relates in particular to a composition comprising Aronia extract and selenium for stimulating the immune system, and pharmaceutical or nutraceutical compositions comprising the same.THE PRIOR ART[0002]Aronia (chokeberry) is a deciduous shrub which belongs to the plant family Rosaceae. Within the genus Aronia several species and hybrids are known, such as Aronia melanocarpa (black chokeberry), Aronia arbutifolia (red chokeberry), and Aronia x prunifolia (purple chokeberry). The Aronia fruits are small pomes and the juice of it is known to be astringent and to have a high content of vitamin C and other antioxidants.[0003]Due to their intensive fruit color Aronia is used as a coloring agent for beverages and other food products, as disclosed e.g. in U.S. Pat. No. 6,703,056, WO 2005 058052, and WO 2006 138419. Beside this, the Aronia fruits have awaken interest due to their antioxidative qualities. For example Aroni...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K33/04A61P29/00A61P31/04A61P31/10A61P31/12A61P19/02A61P37/00A61P1/00A61P27/02A61P25/00A61P17/00A61P37/06A61K33/30A61P33/00
CPCA61K33/04A61K33/30A61K36/73A61K45/06A61K2300/00A61P1/00A61P1/02A61P1/04A61P1/16A61P3/10A61P9/00A61P9/10A61P11/00A61P11/02A61P11/06A61P13/12A61P17/00A61P17/04A61P17/06A61P19/00A61P19/02A61P19/10A61P21/00A61P25/00A61P27/02A61P27/06A61P29/00A61P31/04A61P31/10A61P31/12A61P31/18A61P33/00A61P35/00A61P37/00A61P37/02A61P37/06A61P37/08Y02A50/30
Inventor ESCHMANN, KLAUSBEUTH, JOSEF
Owner URSAPHARM ARZNEIMITTEL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap