Methods and Apparatuses for the Treatment of Glaucoma using visible and infrared ultrashort laser pulses

Abstract

Transcorneal and fiberoptic laser delivery systems and methods for the treatment of eye diseases wherein energy is delivered by wavelengths transparent to the cornea to effect target tissues in the eye for the control of intraocular pressure in diseases such as glaucoma by delivery systems both external to and within ocular tissues. External delivery may be effected under gonioscopic control. Internal delivery may he controlled endoscopically or fiberoptically, both systems utilizing femtosecond laser energy to excise ocular tissue. The femtosecond light energy is delivered to the target tissues to be treated to effect precisely controlled photodisruption to enable portals for the outflow of aqueous fluid in the case of glaucoma in a manner which minimizes target tissue healing responses, inflammation and scarring.

Description

CROSS REFERENCE TO RELATED APPLICATION[0001]This application is based, in part, on U.S. provisional application No. 61 / 482,824 entitled TREATMENT SYSTEMS, DEVICES AND METHODS FOR THE FEMTOSECOND VISIBLE AND INFRARED LASER LIGHT TREATMENT OF GLAUCOMA, filed May 5, 2011, which is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]The present invention pertains generally to methods and procedures for use in ophthalmic surgery. More particularly, the present invention pertains to the use of laser devises for photodisruption tissue in the eye. The present invention is particularly, but not exclusively, useful for an ophthalmic surgical procedure involving transcorneal or fiberoptic photodisruption of tissue of the corneo scleral angle as a treatment for glaucoma.BACKGROUND OF THE INVENTION[0003]Glaucoma refers to a series of relatively common eye disorders in which pressure within the eye is sufficiently high as to result in damage to sensitive intraocular struc...

AI Technical Summary

Benefits of technology

[0014]The present disclosure provides for the delivery of photodisruptive fluence levels of visible or infrared photons to the precise point of the target tissue of the eye by direct or fiberoptic delivery systems without impinging upon the overlying or surrounding tissue or upon the tissue at the region of beam entry into the eye for the purpose of effecting removal of select tissue in precise shapes and depths. Ultrashort laser pulses are directed into the eye either through the cornea or ab internally via fibers to enable laser radiation, including visible and infrared ra

Problems solved by technology

The elevation of intraocular pressure ultimately leads to irreversible destruction of the optic nerve.

In the absence of treatment, the eventual outcome is total loss of vision often accompanied by severe eye pain.

This results in an elevation of intraocular pressure in the eye.

Increased intraocular pressure can lead to damage of the optic nerve and eventual blindness.

However, these drainage or “filtering” procedures not only increase the risk of causing a lens cataract, but often fail by virtue of their closure resulting from the healing of the very wound created for gaining access to the surgical site.

Ab interno surgical procedures, also, if not adequately stealth eventually fail.

Later, a cavitation bubble forms and eventually collapses.

However, successful use of ultrashort laser pulses, such as those produced by a FS laser, in vivo to produce channels in the TM to relieve glaucoma has not been demonstrated by the work discussed above and presents challenges not present in those experimental studies.

The challenges of delivering adequate photodisruptive energy in precise patterns in shapes and depths include (a) the curved surface of the target, (b) the target lies beyond the critical angle of visible ocular structures seen through the cornea unaided, (c) optical coupling systems are necessary to visualize and target the intended treatment sites, e.g. trabecular meshwork and Schlemm's canal, (d) the location of Schlemm's canal may be difficult to establish particularly as it lies behind the optically significant trabecular meshwork, (e) once the inner wall of Schlemm's canal therefore the “blood aqueous barrier”, is penetrated, blood components may obscure the optical pathway for any future optical viewing and / or treating beams.

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