Differentiation inducer to brown-like adipocyte of white adipocyte

Abstract

To provide a differentiation inducer to brown-like adipocytes of white adipocytes containing a novel compound having an excellent differentiation induction action to brown-like adipocytes of white adipocytes as compared with resveratrol.A differentiation inducer to brown-like adipocytes of white adipocytes which is a reaction product of hydroxystilbenes and sinapic acid and contains a compound represented by Formula (1) or a pharmacologically permissible salt thereof:[Chemical Formula 1]in which, in Formula (1), R1 to R4 represents a hydrogen atom, a hydroxy group, a saturated or unsaturated, linear or branched alkoxy group having 1 to 10 carbon atoms, or a saturated or unsaturated, linear or branched alkyl group having 1 to 10 carbon atoms and R1 to R4 each may be the same or different.

Description

BACKGROUND OF THE INVENTION[0001]1. Field of the Invention[0002]The present invention relates to a differentiation inducer to brown-like adipocytes of white adipocytes, the differentiation inducer which contains a reaction product of hydroxystilbenes and sinapic acid obtained by a synthesis method which is a very simple method and is applicable also to foods.[0003]2. Description of the Background Art[0004]Adipocytes constituting the adipose tissue of mammals include two kinds of adipocytes, white adipocytes and brown adipocytes. The white adipocytes mainly have a role of accumulating the chemical energy taken in the form of triglyceride. On the other hand, the brown adipocytes have a role of converting the accumulated energy to heat. The brown adipocytes generate from myoblasts and are colored brown due to a large number of mitochondria contained in the cells. The brown adipocytes generate heat by the action of Uncoupling protein 1 (UCP1) expressed in the mitochondria (Non-patent Li...

AI Technical Summary

Benefits of technology

The compound represented by Formula (1) is a new metabolic syndrome treatment and prevention substance that is better than other compounds at inducing the differentiation of white adipocytes to brown-like adipocytes. This differentiation action is important because it leads to improved metabolism and reduced adiposity. The compound can be used in food, pharmaceutical drugs, or quasi drugs to prevent or improve metabolic syndrome.

Problems solved by technology

However, it is difficult to induce the differentiation of the white adipocytes to the brown-like adipocytes.

In addition, in all the methods above, the differentiation induction effect is limited only in subcutaneous adipocytes.

Moreover, although a compound having an expression amplification effect of the UCP1 gene to the human visceral adipocytes has been reported in Patent Literature 1, the working concentration is very high, so that it is difficult to achieve the effective concentration in the living body and bronzing of the white adipocytes is not referred to.

However, under the circumstances where there arises a doubt as a result of an experiment to Macacus rhesus as to where the calorie restriction itself has an effect useful for life extension (Non-Patent Literature 6), the calorie restriction effect through sirtuin to human beings of the resveratrol is not also certain.

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