Combination therapy for neoplasia treatment

US20140255413A1Inactive Publication Date: 2014-09-11BOEHRINGER INGELHEIM INT GMBH
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
BOEHRINGER INGELHEIM INT GMBH
Publication Date
2014-09-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to an insulin-like growth factor (IGF) receptor antagonist for use in the treatment of prostate neoplasia, including benign prostatic hyperplasia (BPH), prostate cancer, and particularly CRPC, wherein the antagonist is used in combination with an androgen receptor antagonist. An embodiment of the invention is where the androgen receptor antagonist is enzalutamide.
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Description

[0001] The present invention relates to the pharmaceutical treatment of neoplasia, including benign and malignant tumors.BACKGROUND OF THE INVENTION

[0002] Prostate cancer is the most common malignancy diagnosed in males and a leading cause of mortality in western countries (American Cancer Society, 2010 (http: / / www.cancer.org / acs / groups / content / ©epidemiologysurveilance / documents / document / acspc-026238.pdf)). Androgens and stimulation of their receptor, androgen receptor (AR), are essential for the development and function of the normal prostate gland, and the development and progression of prostate cancer (reviewed in Basu S et al., Horm Cancer. 2010 October; 1(5):223-8.; Yadav N et al., Minerva Urol Nefrol. 2012 March; 64(1):35-49). For metastatic prostate cancer, androgen deprivation therapy remains the standard treatment. Despite the fact that initially more than 90% of patients respond to androgen deprivation therapy, the clinical benefits are temporary with tumors becoming refract...

Claims

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