Implantable medical devices comprising bio-degradable alloys with enhanced degradation rates
a biodegradable alloy and medical device technology, applied in the field of biodegradable materials, can solve the problems of limited internal use of medical implants, many devices for fixing bones become problematic, and long-lasting medical implants are not always desirabl
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[0111]Background: Biodegradable metal systems have been developed for use in cardiovascular, orthopedic, surgical and other applications. The advantage of biodegradable metals are that they have high strength and are dissolved by the body and excreted over time until they are completely eliminated from the body. These materials are extremely useful where an implant is needed for a short period of time, such as for bone fixation or artery repair, and can have negative impacts after healing has take place at the implant site. Stents can cause a stenotic lesion if left in place long after they no longer serve a function and bone fixation devices can cause long term discomfort and are frequently removed after they are no longer required. An example of a biodegradable metal system is U.S. Pat. No. 8,246,762 which discloses biodegradable metals for implant that degrade from the surface and consequently do not lose bulk properties of the non-degraded portion of the implant.
[0112]The degrad...
example 2
[0119]Fabrication of a biodegradable material with enhanced degradation rates may be facilitated through the use of a partial pressure of a gaseous reactive component during the fabrication process. For example, a procedure for the initial fabrication of a metal alloy is to place some or all of the desired components of the alloy into the crucible of a vacuum induction furnace, evacuate the furnace and melt the components under vacuum and / or with a partial pressure of argon. Without being bound to any particular theory, it is recognized in the present invention a partial pressure of argon can be used to minimize evaporative loss of the desired components and to prevent metal plasma forming in the furnace chamber which would cause damage to the furnace. After the alloy is fully melted and mixed, it is poured into a mold and cooled.
[0120]In some embodiments, it is desirable to add the some components of the metal alloy at a later stage of the melting process. To add components to the ...
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