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High Fluoride Ion Oral Care Composition and Method for Maintaining Anticaries Activity

a technology of oral care and fluoride ion, which is applied in the direction of drug compositions, dentistry, digestive system, etc., can solve the problems of tooth sensitivity among consumers, difficulty in maintaining the effective properties of fluoride in oral care compositions that also include such sensitivity agents, and otherwise at a higher risk of dental decay than the general population

Inactive Publication Date: 2015-01-22
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The composition achieves high fluoride recovery and desirable physical properties, maintaining fluoride's anticaries activity and sensitivity relief in a single, easy-to-use formulation, even after four weeks.

Problems solved by technology

Some patients often suffer from either more aggressive caries, or are otherwise at a higher risk of dental decay than the general population.
However, a potential complication encountered with any dental applications is that of tooth sensitivity among consumers, for various health-related reasons.
However, while teeth sensitivity agents as noted above can be effective if they are added in requisite effective treatment amounts, it is difficult to maintain the effective properties of the fluoride in an oral care composition that also includes such a sensitivity agent.
On the other hand, if more solvent is added, the composition changes and tends to lose the desirable physical characteristics associated with an acceptable over-the-counter or prescription dentifrice having both such components.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0046]Potassium nitrate at 5 wt % was added to a toothpaste formulation for anticaries and sensitivity treatment use. The formulation was targeted to include fluoride in the range of about 5,000 ppm or more. The formulation was made by providing the following components to an aqueous-based formulation as follows and as shown in Table 1 in comparison with a traditional sensitivity formulation (Comparative Formulation A) that contains a standard concentration of fluoride ions (1,100 ppm):

TABLE 1Comparative Formulation AComponents(Sensitivity)Formulation 1Humectant (sorbitol)44.5010.00Gum (xanthan)1.201.00Water25.15766.05Sodium Fluoride0.243 (1,100 ppm F−)1.10 (5,000 ppm F−)Potassium Nitrate5.005.00Sodium Saccharin0.400.35Dye0.300.30Silica21.0014.00Sodium Lauryl Sulfate1.201.20Flavor1.001.00Total100.00100.00

[0047]Results showed that when a standard fluoride concentration was used (1,100 ppm) with 5% of sodium nitrate desensitizing agent, as in Comparative Formulation A, the composition...

example 2

[0049]Formulation 2 was made as follows, with the difference between Formulations 1 and 2 in the hydrocolloid used. In Formulation 2, carrageenan gum comprising sulfate was used instead of xanthan gum, as set forth below:

TABLE 2ComponentsFormulation 1Formulation 2Humectant (sorbitol)10.0010.00Gum 1.00 (xanthan gum)1.00 (carrageenan gum)Water66.0566.05Sodium Fluoride1.10 (5,000 ppm F−)1.10 (5,000 ppm F−)Potassium Nitrate5.005.00Sodium Saccharin0.350.35Dye0.300.30Silica14.0014.00Sodium Lauryl Sulfate1.201.20Flavor1.001.00Total100.00100.00

[0050]Formulation 2 was found to exhibit the same desirable physical properties as Formulation 1, with the added benefit that the fluoride recovery remained extremely high after four weeks. While fluoride recovery was already high after four weeks using xanthan gum (89%), with the carrageenan gum comprising sulfate substituted for the xanthan gum, fluoride recovery after for weeks was even higher (about 100%).

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Abstract

An oral care composition and method of maintaining anticaries activity of fluoride ion in an oral care composition are described. An oral care composition comprises a fluoride ion source sufficient to maintain a high fluoride content in the composition, an effective amount of a desensitizing agent and water. A method of maintaining anti caries activity of fluoride km in an oral care composition comprises providing an oral care composition comprising fluoride ions, an effective amount of a desensitizing agent and water.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application is a continuation of U.S. patent application Ser. No. 11 / 479,678, filed Jun. 30, 2006, no allowed, the entirety of which is hereby incorporated by reference.BACKGROUND OF THE INVENTION[0002]Dental caries is a major dental disease that affects the majority of the population. In the early part of the 20th century investigators discovered that fluoride was effective in reducing the incidence of caries. Since that time, fluoride research has developed, and it is now well accepted that fluoride treatments benefit dental health.[0003]Fluoride has several principal anti-cariogenic mechanisms. For example, in early dental caries, the acids formed by bacteria cause demineralization of the enamel (breakdown of the tooth structure with a loss of mineral content). Fluoride can enhance remineralization and inhibit demineralization during the earliest stages of the carious process. Fluoride from fluoridated water or fluoride too...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61Q11/00A61K8/25A61K8/21A61K8/73A61K8/19
CPCA61K8/21A61K8/19A61K8/73A61K2800/48A61K8/25A61K2800/28A61Q11/00A61K8/42A61K8/27A61K8/34A61P1/02A61P31/00
Inventor JOZIAK, MARILOU T.FISHER, STEVEN W.
Owner COLGATE PALMOLIVE CO
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