System and method for optogenetic therapy

a technology of optogenetic therapy and system and method, applied in the field of system and method of optogenetic therapy, can solve the problems of significant clinical downsides and inhibition of such signals

Inactive Publication Date: 2015-09-03
CIRCUIT THERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Electrical stimulation techniques, on the other hand, may be more precise from an interventional time scale perspective, but they generally are not cell type specific and may therefore involve significant clinical downsides.
Conversely, membrane hyperpolarization leads to the inhibition of such signals.

Method used

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  • System and method for optogenetic therapy
  • System and method for optogenetic therapy
  • System and method for optogenetic therapy

Examples

Experimental program
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Embodiment Construction

[0042]Referring to FIG. 1, from a high-level perspective, an optogenetics-based neuromodulation intervention involves determination of a desired nervous system functional modulation which can be facilitated by optogenetic excitation and / or inhibition (2), followed by a selection of neuroanatomic resource within the patient to provide such outcome (4), delivery of an effective amount of polynucleotide comprising a light-responsive opsin protein which is expressed in neurons of the targeted neuroanatomy (6), waiting for a period of time to ensure that sufficient portions of the targeted neuroanatomy will indeed express the light responsive opsin protein upon exposure to light (8), and delivering light to the targeted neuroanatomy to cause controlled, specific excitation and / or inhibition of such neuroanatomy by virtue of the presence of the light-responsive opsin protein therein (10).

[0043]While the development and use of transgenic animals has been utilized to address some of the afo...

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Abstract

Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.

Description

RELATED APPLICATION DATA[0001]This is a continuation application of International Application No. PCT / US2013 / 000262, filed on Nov. 21, 2013, which claims priority to U.S. Provisional Application Ser. No. 61 / 729,283, filed on Nov. 21, 2012. The foregoing applications are hereby incorporated by reference into the present application in their entirety. Priority to the aforementioned applications is hereby expressly claimed in accordance with 35 U.S.C. §§119, 120, and 365 and any other applicable statutes.INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED ELECTRONICALLY[0002]Incorporated by reference in its entirety is a computer-readable nucleotide / amino acid sequence listing submitted concurrently herewith, and identified as follows: One 122 KiloByte ASCII (Text) file named “14—445—993_SeqList_ST25.txt” created on Mar. 13, 2015.FIELD OF THE INVENTION[0003]The present invention relates generally to systems, devices, and processes for facilitating various levels of control over cells and ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N5/06A61K38/16
CPCA61N5/0622A61N5/0601A61K38/168A61K48/00A61N2005/0626A61N2005/0643A61N2005/0651A61K38/16A61N5/067A61N1/0551A61N1/3605A61N5/062A61K38/164A61K38/177A61P9/12A61N2005/0612A61N2005/0627A61N2005/063A61K41/00A61N2005/0665A61K41/0057A61M25/0105A61M37/0015A61M2037/0023A61M2037/0061A61N2005/0631A61K48/0075A61B17/00234A61B17/3403A61B2017/3413A61M5/142A61M5/20A61M25/0147A61M2205/3576A61M2205/50A61N1/36053A61N2005/0653
Inventor DELP, SCOTTDEISSEROTH, KARLANDERSEN, DAN
Owner CIRCUIT THERAPEUTICS
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