Nanoparticle drug conjugates

a technology of nanoparticles and conjugates, applied in the field of nanoparticle conjugates, can solve the problems of poor interstitial permeation of liposomes
US20150343091A1Active Publication Date: 2015-12-03MEMORIAL SLOAN KETTERING CANCER CENT +1
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Patent Information

Authority / Receiving Office
US ยท United States
Current Assignee / Owner
MEMORIAL SLOAN KETTERING CANCER CENT
Publication Date
2015-12-03

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Abstract

Described herein are nanoparticle drug conjugates (NDCs), which, in certain embodiments, comprise a non-toxic, multi-modality, clinically proven silica-based nanoparticle platform with covalently attached drug molecules / moieties. The nanoparticle drug conjugates (NDCs) demonstrate imaging capability and targeting ligands which efficiently clear through the kidneys. Furthermore, the conjugates incorporate therapeutic agents for cancer detection, prevention, and / or treatment.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority to and the benefit of, and incorporates herein by reference in their entireties, U.S. Provisional Patent Application Nos. 62 / 004,738 and 62 / 094,923, filed May 29, 2014 and Dec. 19, 2014, respectively.FIELD OF THE INVENTION

[0002] This invention relates generally to nanoparticle conjugates for delivery of therapeutic agents (e.g., targeted drug release) for the detection, prevention, and treatment of cancer and other diseases.BACKGROUND OF THE INVENTION

[0003] Nanotherapeutic delivery vehicles are typically macro- or supra-molecular multicomponent systems, ranging in size from 1-1,000 nm, that are either inherently therapeutic (e.g., no active pharmaceutical ingredient) or function as therapeutic delivery systems. To date, liposomal nanoparticles and biologics comprise a large proportion of the number of FDA-approved products or products in clinical trials used to treat a variety of cancer types, while a number...

Claims

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